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• W1539188813 abstract "Background Phlebotomy represents the standard treatment option for iron overload in hemochromatosis ( HC ). Recently, red blood cell ( RBC ) apheresis has increasingly been used to remove iron. In this study we evaluated the depletion program of the newly developed S pectra O ptia device. Study Design and Methods Adult male patients (n = 11) with HC were RBC depleted with the S pectra O ptia device ( T erumo BCT ). In total, 24 procedures were performed. A volume of 300 to 550 mL of RBC s was withdrawn per single treatment. Results No significant adverse events were recorded. A median blood volume of 857.3 ± 23.3 mL was processed. The median procedure time was 12.0 ± 0.4 minutes. The mean reduction of H ct value in each procedure was approximately 6% ( H ct pre 42.6 ± 0.5% vs. H ct post 36.6 ± 0.6%) and iron removed per procedure was 405.2 ± 23.3 mg. Conclusion The S pectra O ptia device proved to be highly efficient in depleting RBCs in HC patients and allows for short procedure time. The O ptia device can be safely used in this clinical setting. We recommend its use in case of severe iron overload if rapid iron depletion needs to be achieved and in case of cardiac compromise due to less blood volume removed." @default.
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• W1539188813 date "2014-11-21" @default.
• W1539188813 modified "2023-10-12" @default.
• W1539188813 title "Iron depletion with a novel apheresis system in patients with hemochromatosis" @default.
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• W1539188813 doi "https://doi.org/10.1111/trf.12949" @default.
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