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• W1539194804 startingPage "681" @default.
• W1539194804 abstract "The DNA photoproduct responsible for the ultraviolet (u.v.)-induced targeted −1 frameshift mutation is unknown. Based on mutagenesis studies by others, we surmised that this lesion might be found in high abundance in single-stranded DNA. u.v. irradiation of the single-stranded alternating copolymer poly[d(G-T)]yielded a photoproduct that was characterized in detail. It consists of a thymine-thymine cyclobutane dimer of predominantly cis-syn configuration occurring between non-adjacent thymidyl residues on the same strand. Its formation is strongly inhibited in double-stranded DNA. A similar u.v. photoproduct was obtained in higher yield from the polypyrimidine alternating copolymer poly[d(C-T)]under conditions in which it is single-stranded. It is proposed that replication across the unrepaired photoproduct:" @default.
• W1539194804 created "2016-06-24" @default.
• W1539194804 creator A5085670338 @default.
• W1539194804 creator A5088091814 @default.
• W1539194804 date "1988-04-01" @default.
• W1539194804 modified "2023-10-18" @default.
• W1539194804 title "Ultraviolet-induced dimerization of non-adjacent pyrimidines" @default.
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• W1539194804 doi "https://doi.org/10.1016/0022-2836(88)90480-9" @default.
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• W1539194804 hasPublicationYear "1988" @default.
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