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• W1539200465 abstract "In the chapter, we hereby provide a brief review about RNA interference (RNAi) and elucidate its therapeutic applications. The enzymatic synthesis of double-stranded RNA in vitro will be discussed. We also describe how to design and select short interfering RNA (siRNA) sequences. In addition, we also introduce a DNA-directed RNAi (ddRNAi) system, which is designed for the generation of small hairpin RNAs in mammalian cells and is an efficient approach to allow fast and easy expression of hairpin oligonucleotides for therapeutic purpose. Moreover, various strategies for delivery of siRNA to target cells are discussed in this chapter. Under the consideration of distinct need of different diseases, use of transient or stable transfection onto living organism will be introduced. Finally, we will discuss the application of RNAi in clinical or preclinical trial. Some ongoing therapeutic models, efficacy or limitation for RNAi will be demonstrated and clarified." @default.
• W1539200465 created "2016-06-24" @default.
• W1539200465 creator A5006125769 @default.
• W1539200465 creator A5011616756 @default.
• W1539200465 creator A5045281345 @default.
• W1539200465 date "2011-06-22" @default.
• W1539200465 modified "2023-10-16" @default.
• W1539200465 title "Gene Therapy Using RNAi" @default.
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