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- W1539280053 abstract "TheletA(ccdA) andletD(ccdB) genes of the F plasmid, located just outside the sequence essential for replication, contribute to stable maintenance of the plasmid inEscherichia colicells. TheletDgene product acts to inhibit partitioning of chromosomal DNA and cell division by inhibiting DNA gyrase activity, whereas theletAgene product acts to reverse the inhibitory activity of theletDgene product. To identify the host factor(s) involved in this process, we analyzed the mutants that escapedletDexpression and their suppressor, and found that the threeE. coligenestldD,tldEandzfiAparticipate in the process, in addition to thegroEgenes we reported previously. ThetldDandtldEmutations made cells tolerant forletDexpression, as didgroESmutations, while the mutation in thezfiAgene madetldD,tldEandgroESmutants LetD sensitive. We hypothesize that these gene products are factors that modulate activity of DNA gyrase along with theletDgene product; thezfiAgene product acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase, while thetldD,tldEandgroEgene products act to suppress the inhibitory activity of thezfiAgene product. ThetldD,tldE, andzfiAgenes are located at 70.4, 96.0 and 58.2 minutes on theE. colichromosome, respectively, and code for proteins with relative molecular masses of 51,000, 48,000 and 6800, respectively.tldDis a novel gene, but thetldEandzfiAgenes proved to be thepmbAgene (production of Microcin B17) and thecsrAgene (carbon storage regulator), respectively." @default.
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- W1539280053 date "1996-03-01" @default.
- W1539280053 modified "2023-09-23" @default.
- W1539280053 title "vidence for Involvement of Genes , and a Previously Unrecognized Gene , in the Control of DNA Gyrase by ( ) of Sex Factor F" @default.
- W1539280053 doi "https://doi.org/10.1006/jmbi.1996.0103" @default.
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