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• W1539291018 abstract "Subarachnoid hemorrhage due to a rupture of cerebral aneurysm is a severe disease with morbidity and mortality. Although, if patients' conditions are fair before surgery, they are rather safely operated by either clipping or coiling, vasospasm remains as a major complication of this disease. There are still many patients who suffer from vasospasm causing neurological deficits. Both strong vasoconstriction and inflammation are involved in the pathphysiological mechanism of vasospasm. In 1992 we had reported specific effects of a vasodilating drug “fasudil” in the treatment of vasospasm, but mechanisms how fasudil ameliorated vasospasm had not been clearly understood as it is today. RhoA/Rho kinase had been found in 1996 and was revealed to act as molecular on-off switches that control multiple signaling pathways. Upregulated Rho kinase is known to be involved in various diseases from vascular disease to cancer. In cerebral vasospasm, upregulated Rho kinase was found to be involved in many aspects, such as increased calcium sensitivity, reduced production of nitric oxide, migration of inflammatory cells and their production of superoxide anions and increased blood viscosity. Interestingly, fasudil was found to specifically increase cerebral blood flow in the area with vasospasm. In the present paper pathophysiological mechanism of vasospasm and effects of fasudil are reviewed and mechanisms why fasudil increases cerebral blood flow in the area with vasospasm without so much changing that of normal flow area will be discussed." @default.
• W1539291018 created "2016-06-24" @default.
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• W1539291018 date "2012-03-16" @default.
• W1539291018 modified "2023-09-26" @default.
• W1539291018 title "Fasudil (a Rho Kinase Inhibitor) Specifically Increases Cerebral Blood Flow in Area of Vasospasm After Subarachnoid Hemorrhage" @default.
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• W1539291018 doi "https://doi.org/10.5772/34012" @default.
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