FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539303311> ?p ?o ?g. }

• W1539303311 endingPage "231" @default.
• W1539303311 startingPage "225" @default.
• W1539303311 abstract "Objective: An aqueous-organic precipitation technique was developed for preparing bioadhesive hydroxypropyl methylcellulose (HPMC) microparticles for nasal delivery using a low viscosity grade of HPMC K100LV. Methods: The method involved the preparation of HPMC microparticles by precipitating the gelled HPMC into acetone. The effect of different processing variables of precipitation technique on in-vitro bioadhesive performance of HPMC microparticles was studied. Results: In-vitro assessment of adhesion properties of the microparticles showed that the process of co-precipitation greatly increased the adhesiveness in comparison with unprocessed HPMC powder. Bioadhesive performance was found to be dependent on the dehydrated state of the polymer following precipitation, with the most dehydrated formulations using the slowest (dropwise) rate of addition of the HPMC gel to acetone, showing lower water uptake and greater adhesive performance. It would be expected therefore, that the interaction of acetone and water would be instantaneous and complete, resulting in an extremely efficient dehydration process and a collapse of HPMC matrix structure, forming a physical barrier to subsequent rehydration. Conclusion: This formulation afforded the highest bioadhesion score in the test employed, which was designed to represent the dynamic interplay of hydration, entanglement of polymer and mucin, and rheological flow which a formulation would experience on the nasal mucosal surface. Keywords: Bioadhesive microparticles, Water sorption, Nasal drug delivery, Dynamic adhesion, Co-precipitation technique, HPMC polymer, Differential scanning calorimetry." @default.
• W1539303311 created "2016-06-24" @default.
• W1539303311 creator A5023453851 @default.
• W1539303311 creator A5035124684 @default.
• W1539303311 date "2014-07-29" @default.
• W1539303311 modified "2023-09-28" @default.
• W1539303311 title "WATER UPTAKE PERFORMANCE OF BIOADHESIVE HPMC MICROPARTICLES FOR NASAL ADMINISTRATION USING DIFFERENT PROCESSING VARIABLES OF CO-PRECIPITATION TECHNIQUE" @default.
• W1539303311 cites W133519420 @default.
• W1539303311 cites W1482441247 @default.
• W1539303311 cites W1534162975 @default.
• W1539303311 cites W1963762209 @default.
• W1539303311 cites W1978128526 @default.
• W1539303311 cites W1982572529 @default.
• W1539303311 cites W1988373919 @default.
• W1539303311 cites W1990525490 @default.
• W1539303311 cites W2004173569 @default.
• W1539303311 cites W2004895912 @default.
• W1539303311 cites W2005154914 @default.
• W1539303311 cites W2009604815 @default.
• W1539303311 cites W2019031932 @default.
• W1539303311 cites W2021978496 @default.
• W1539303311 cites W2026399240 @default.
• W1539303311 cites W2027715406 @default.
• W1539303311 cites W2033903461 @default.
• W1539303311 cites W2035224718 @default.
• W1539303311 cites W2035852125 @default.
• W1539303311 cites W2038780553 @default.
• W1539303311 cites W2039114837 @default.
• W1539303311 cites W2052526822 @default.
• W1539303311 cites W2062246286 @default.
• W1539303311 cites W2074971761 @default.
• W1539303311 cites W2075035823 @default.
• W1539303311 cites W2080814318 @default.
• W1539303311 cites W2084257482 @default.
• W1539303311 cites W2087247100 @default.
• W1539303311 cites W2088320679 @default.
• W1539303311 cites W2125607348 @default.
• W1539303311 cites W2151650844 @default.
• W1539303311 cites W2159375637 @default.
• W1539303311 cites W2318801071 @default.
• W1539303311 cites W2492725256 @default.
• W1539303311 cites W2531526206 @default.
• W1539303311 cites W2595177515 @default.
• W1539303311 cites W290573391 @default.
• W1539303311 cites W73500475 @default.
• W1539303311 cites W2404822233 @default.
• W1539303311 hasPublicationYear "2014" @default.
• W1539303311 type Work @default.
• W1539303311 sameAs 1539303311 @default.
• W1539303311 citedByCount "0" @default.
• W1539303311 crossrefType "journal-article" @default.
• W1539303311 hasAuthorship W1539303311A5023453851 @default.
• W1539303311 hasAuthorship W1539303311A5035124684 @default.
• W1539303311 hasConcept C107054158 @default.
• W1539303311 hasConcept C121332964 @default.
• W1539303311 hasConcept C127413603 @default.
• W1539303311 hasConcept C153294291 @default.
• W1539303311 hasConcept C159985019 @default.
• W1539303311 hasConcept C171250308 @default.
• W1539303311 hasConcept C178790620 @default.
• W1539303311 hasConcept C185592680 @default.
• W1539303311 hasConcept C192562407 @default.
• W1539303311 hasConcept C2776634624 @default.
• W1539303311 hasConcept C2778540859 @default.
• W1539303311 hasConcept C2778551929 @default.
• W1539303311 hasConcept C2779227376 @default.
• W1539303311 hasConcept C2781213060 @default.
• W1539303311 hasConcept C39519442 @default.
• W1539303311 hasConcept C42360764 @default.
• W1539303311 hasConcept C43617362 @default.
• W1539303311 hasConcept C521977710 @default.
• W1539303311 hasConcept C68928338 @default.
• W1539303311 hasConcept C97355855 @default.
• W1539303311 hasConceptScore W1539303311C107054158 @default.
• W1539303311 hasConceptScore W1539303311C121332964 @default.
• W1539303311 hasConceptScore W1539303311C127413603 @default.
• W1539303311 hasConceptScore W1539303311C153294291 @default.
• W1539303311 hasConceptScore W1539303311C159985019 @default.
• W1539303311 hasConceptScore W1539303311C171250308 @default.
• W1539303311 hasConceptScore W1539303311C178790620 @default.
• W1539303311 hasConceptScore W1539303311C185592680 @default.
• W1539303311 hasConceptScore W1539303311C192562407 @default.
• W1539303311 hasConceptScore W1539303311C2776634624 @default.
• W1539303311 hasConceptScore W1539303311C2778540859 @default.
• W1539303311 hasConceptScore W1539303311C2778551929 @default.
• W1539303311 hasConceptScore W1539303311C2779227376 @default.
• W1539303311 hasConceptScore W1539303311C2781213060 @default.
• W1539303311 hasConceptScore W1539303311C39519442 @default.
• W1539303311 hasConceptScore W1539303311C42360764 @default.
• W1539303311 hasConceptScore W1539303311C43617362 @default.
• W1539303311 hasConceptScore W1539303311C521977710 @default.
• W1539303311 hasConceptScore W1539303311C68928338 @default.
• W1539303311 hasConceptScore W1539303311C97355855 @default.
• W1539303311 hasIssue "7" @default.
• W1539303311 hasOpenAccess W1539303311 @default.
• W1539303311 hasRelatedWork W1604663875 @default.
• W1539303311 hasRelatedWork W1915461977 @default.
• W1539303311 hasRelatedWork W2003968063 @default.

• next