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- W1539311273 abstract "SUMMARY Objective: Determine the susceptibility to five fluoroquinolones and crossresistance of pneumococcus clinical isolates with different penicillin susceptibilities gathered in a community-based study . Design: Cross-sectional survey. Materials: Two hundred and thirty one (231) isolates were obtained from respiratory secretions or blood specimens from 231 patients with acquired acute respiratory infection or bacteremia. Outcome measures: In vitro susceptibility to penicillin (PEN), ciprofloxacin (CIP), levofloxacin (LEV), gatifloxacin (GAT), moxifloxacin (MOX) and gemifloxacin (GEM) was determined with minimal inhibitory concentration (MIC) using the E test. Results: 42% of the isolates showed decreased susceptibility to PEN. The lowest antibiotic concentration that inhibited 90% of the isolates was 3 µg/ml (for CIP), 1 µg/ml (for LEV), 0.25 µg/ml (for GAT), 0.125 µg/ ml (for MOX) and 0.032 µg/ml (for GEM). Median MIC for LEV, GAT, MOX and GEM increased with decreasing susceptibility to CIP. Susceptibility to CIP was similar between penicillin-susceptible and penicillin-resistant pneumococci. Conclusion: Third and fourth generation fluoroquinolones showed very high inhibitory activity, higher than that for CIP, for both penicillinsusceptible and penicillin-resistant pneumococci. We noted crossresistance among fluoroquinolones." @default.
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- W1539311273 date "2005-07-01" @default.
- W1539311273 modified "2023-10-01" @default.
- W1539311273 title "Actividad de las fluoroquinolonas en aislamientos clínicos de Streptococcus pneumoniae con diferente susceptibilidad a la penicilina: Estudio epidemiológico en cinco ciudades de la República Mexicana" @default.
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