FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539346908> ?p ?o ?g. }

• W1539346908 endingPage "9076" @default.
• W1539346908 startingPage "9072" @default.
• W1539346908 abstract "To elucidate the mechanism by which C4b-binding protein inhibits the cofactor activity of protein S for anticoagulant-activated protein C, the interactions between protein S, activated protein C, and C4b-binding protein were studied using solid-phase enzyme immunoassays. Both activated protein C and C4b-binding protein bound to protein S fixed to microplate wells. C4b-binding protein did not inhibit the binding of activated protein C to protein S, nor did activated protein C inhibit the binding of C4b-binding protein to protein S. Activated protein C bound to a protein S-C4b-binding protein complex which was cross-linked with a chemical reagent as well as it bound to free protein S. Protein S-C4b-binding protein complex competitively inhibited activated protein C-binding to free protein S and also the cofactor activity of free protein S. Immunoblotting analysis showed ternary complex formation with protein S, C4b-binding protein, and activated protein C in the liquid phase by treatment with the cross-linking reagent. These findings suggest that the protein S-C4b-binding protein complex inhibits the cofactor activity of free protein S probably by inhibition of functionally active protein S-activated protein C complex formation by the apparent competitive formation of an inactive ternary complex with protein S, C4b-binding protein, and activated protein C." @default.
• W1539346908 created "2016-06-24" @default.
• W1539346908 creator A5017892495 @default.
• W1539346908 creator A5062405573 @default.
• W1539346908 date "1990-06-01" @default.
• W1539346908 modified "2023-10-16" @default.
• W1539346908 title "Inhibition of cofactor activity of protein S by a complex of protein S and C4b-binding protein. Evidence for inactive ternary complex formation between protein S, C4b-binding protein, and activated protein C." @default.
• W1539346908 cites W110124829 @default.
• W1539346908 cites W1439329156 @default.
• W1539346908 cites W1482058108 @default.
• W1539346908 cites W1505301300 @default.
• W1539346908 cites W1519587642 @default.
• W1539346908 cites W1526957198 @default.
• W1539346908 cites W1531637520 @default.
• W1539346908 cites W1563610085 @default.
• W1539346908 cites W1591666324 @default.
• W1539346908 cites W1651976025 @default.
• W1539346908 cites W1812894901 @default.
• W1539346908 cites W181622342 @default.
• W1539346908 cites W1926375428 @default.
• W1539346908 cites W1953483609 @default.
• W1539346908 cites W2000143497 @default.
• W1539346908 cites W2007173891 @default.
• W1539346908 cites W2028074087 @default.
• W1539346908 cites W2038153293 @default.
• W1539346908 cites W2039313371 @default.
• W1539346908 cites W2049622931 @default.
• W1539346908 cites W2060335268 @default.
• W1539346908 cites W2111817213 @default.
• W1539346908 cites W2146923243 @default.
• W1539346908 cites W2155045365 @default.
• W1539346908 cites W2397667542 @default.
• W1539346908 cites W2409538969 @default.
• W1539346908 cites W2416035508 @default.
• W1539346908 doi "https://doi.org/10.1016/s0021-9258(19)38813-1" @default.
• W1539346908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2140568" @default.
• W1539346908 hasPublicationYear "1990" @default.
• W1539346908 type Work @default.
• W1539346908 sameAs 1539346908 @default.
• W1539346908 citedByCount "45" @default.
• W1539346908 countsByYear W15393469082012 @default.
• W1539346908 countsByYear W15393469082013 @default.
• W1539346908 countsByYear W15393469082014 @default.
• W1539346908 countsByYear W15393469082019 @default.
• W1539346908 countsByYear W15393469082023 @default.
• W1539346908 crossrefType "journal-article" @default.
• W1539346908 hasAuthorship W1539346908A5017892495 @default.
• W1539346908 hasAuthorship W1539346908A5062405573 @default.
• W1539346908 hasBestOaLocation W15393469081 @default.
• W1539346908 hasConcept C104317684 @default.
• W1539346908 hasConcept C123894998 @default.
• W1539346908 hasConcept C135604509 @default.
• W1539346908 hasConcept C144647389 @default.
• W1539346908 hasConcept C146033667 @default.
• W1539346908 hasConcept C159654299 @default.
• W1539346908 hasConcept C181199279 @default.
• W1539346908 hasConcept C185592680 @default.
• W1539346908 hasConcept C197957613 @default.
• W1539346908 hasConcept C2776135265 @default.
• W1539346908 hasConcept C2781287897 @default.
• W1539346908 hasConcept C40767141 @default.
• W1539346908 hasConcept C41625074 @default.
• W1539346908 hasConcept C51639874 @default.
• W1539346908 hasConcept C54355233 @default.
• W1539346908 hasConcept C553089730 @default.
• W1539346908 hasConcept C55493867 @default.
• W1539346908 hasConcept C86756495 @default.
• W1539346908 hasConcept C86803240 @default.
• W1539346908 hasConcept C88532467 @default.
• W1539346908 hasConceptScore W1539346908C104317684 @default.
• W1539346908 hasConceptScore W1539346908C123894998 @default.
• W1539346908 hasConceptScore W1539346908C135604509 @default.
• W1539346908 hasConceptScore W1539346908C144647389 @default.
• W1539346908 hasConceptScore W1539346908C146033667 @default.
• W1539346908 hasConceptScore W1539346908C159654299 @default.
• W1539346908 hasConceptScore W1539346908C181199279 @default.
• W1539346908 hasConceptScore W1539346908C185592680 @default.
• W1539346908 hasConceptScore W1539346908C197957613 @default.
• W1539346908 hasConceptScore W1539346908C2776135265 @default.
• W1539346908 hasConceptScore W1539346908C2781287897 @default.
• W1539346908 hasConceptScore W1539346908C40767141 @default.
• W1539346908 hasConceptScore W1539346908C41625074 @default.
• W1539346908 hasConceptScore W1539346908C51639874 @default.
• W1539346908 hasConceptScore W1539346908C54355233 @default.
• W1539346908 hasConceptScore W1539346908C553089730 @default.
• W1539346908 hasConceptScore W1539346908C55493867 @default.
• W1539346908 hasConceptScore W1539346908C86756495 @default.
• W1539346908 hasConceptScore W1539346908C86803240 @default.
• W1539346908 hasConceptScore W1539346908C88532467 @default.
• W1539346908 hasIssue "16" @default.
• W1539346908 hasLocation W15393469081 @default.
• W1539346908 hasOpenAccess W1539346908 @default.
• W1539346908 hasPrimaryLocation W15393469081 @default.
• W1539346908 hasRelatedWork W1492492848 @default.
• W1539346908 hasRelatedWork W1520352463 @default.
• W1539346908 hasRelatedWork W1539346908 @default.
• W1539346908 hasRelatedWork W1554627437 @default.
• W1539346908 hasRelatedWork W187753264 @default.

• next