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- W1539368996 abstract "The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existence of CSCs came from advances in the field of haematological malignancies. Thus far, putative CSCs have been isolated from various solid and non-solid tumours and shown to possess self-renewal, differentiation, and cancer regeneration properties. Although research in the field is progressing extremely fast, proof of concept for the CSC hypothesis is still lacking and key questions remain unanswered, e.g. the cell of origin for these cells. Nevertheless, it is undisputed that neoplastic transformation is associated with genetic and epigenetic alterations of normal cells, and a better understanding of these complex processes is of utmost importance for developing new anti-cancer therapies. In the present review, we discuss the CSC hypothesis with special emphasis on age-associated alterations that govern carcinogenesis, at least in some types of tumours. We present evidence from the scientific literature for age-related genetic and epigenetic alterations leading to cancer and discuss the main challenges in the field." @default.
- W1539368996 created "2016-06-24" @default.
- W1539368996 creator A5003277887 @default.
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- W1539368996 creator A5067955916 @default.
- W1539368996 creator A5084214493 @default.
- W1539368996 creator A5091545004 @default.
- W1539368996 date "2015-01-15" @default.
- W1539368996 modified "2023-09-26" @default.
- W1539368996 title "The crossroads between cancer stem cells and aging" @default.
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