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• W153937327 abstract "The ability of two novel muscarinic agonists, AF150(S) and AF151(S), to (1) enhance matching accuracy in pigeons in a delayed matching-to-sample procedure and (2) reverse deficits associated with scopolamine administration was investigated. There was no effect of either drug alone on matching accuracy over four dose levels (0, 1, 2 and 4 mg/kg) following intraperitoneal (i.p.) injections. Administration of scopolamine (0.03 mg/kg) i.p. impaired matching accuracy across all retention intervals, suggesting that perceptual or attentional processes were disrupted. AF150(S), but not AF151(S), reversed the deficits associated with scopolamine administration. The present results indicate that the cholinergic system may mediate encoding processes and that AF150(S) may be a possible candidate for alleviating some of the cognitive deficits seen in Alzheimer’s disease." @default.
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• W153937327 date "1997-12-01" @default.
• W153937327 modified "2023-10-16" @default.
• W153937327 title "Attenuation of scopolamine-induced deficits in delayed-matching performance by a new muscarinic agonist" @default.
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• W153937327 doi "https://doi.org/10.3758/bf03331942" @default.
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