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- W1539389640 abstract "A growing body of evidence indicates a bidirectional relationship between the neuroendocrine system and immune functions. In this chapter we discuss the interactions between the growth hormone/insulin-like growth factor system and cytokines. Much experimental evidence suggests that both GH and IGF-I have a stimulatory effect on the immune response and on the production of immune (interleukin-2 and interferon-γ) and inflammatory (tumor necrosis factor, interlukin-1, interleukin-6) cytokines. However, the in vivo relevance in humans of these findings has yet to be fully demonstrated. On the other hand, proinflammatory cytokines affect the GH/IGF-I axis. These effects are relevant for the understanding of the mechanisms leading to stunted growth in chronic inflammatory diseases or diseases with recurrent infections in childhood." @default.
- W1539389640 created "2016-06-24" @default.
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- W1539389640 date "2002-01-01" @default.
- W1539389640 modified "2023-09-25" @default.
- W1539389640 title "Reciprocal interactions between the GH/IGF-I system and cytokines" @default.
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- W1539389640 doi "https://doi.org/10.1016/s1567-7443(02)80006-0" @default.
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