Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539403786> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1539403786 endingPage "456" @default.
- W1539403786 startingPage "451" @default.
- W1539403786 abstract "Germ-line mutations of the BRCA1 gene are responsible for a substantial proportion of families with multiple cases of early-onset breast and/or ovarian cancer. Since the isolation of BRCA1 last year, >65 distinct mutations scattered throughout the coding region have been detected, making analysis of the gene time consuming and technically challenging. We have developed a multiplex heteroduplex analysis that is designed to analyze one-quarter of the coding sequence in a single-step screening procedure and that will detect {approximately}50% of all BRCA1 mutations so far reported in breast/ovarian cancer families. We have used this technique to analyze BRCA1 in 162 families with a history of breast and/or ovarian cancer and identified 12 distinct mutations in 35 families. 20 refs., 2 figs., 2 tabs." @default.
- W1539403786 created "2016-06-24" @default.
- W1539403786 creator A5047173565 @default.
- W1539403786 creator A5087937279 @default.
- W1539403786 creator A5091626544 @default.
- W1539403786 date "1996-03-01" @default.
- W1539403786 modified "2023-09-26" @default.
- W1539403786 title "Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis" @default.
- W1539403786 hasPublicationYear "1996" @default.
- W1539403786 type Work @default.
- W1539403786 sameAs 1539403786 @default.
- W1539403786 citedByCount "16" @default.
- W1539403786 countsByYear W15394037862014 @default.
- W1539403786 crossrefType "journal-article" @default.
- W1539403786 hasAuthorship W1539403786A5047173565 @default.
- W1539403786 hasAuthorship W1539403786A5087937279 @default.
- W1539403786 hasAuthorship W1539403786A5091626544 @default.
- W1539403786 hasConcept C104317684 @default.
- W1539403786 hasConcept C121608353 @default.
- W1539403786 hasConcept C134494468 @default.
- W1539403786 hasConcept C2780427987 @default.
- W1539403786 hasConcept C2781188995 @default.
- W1539403786 hasConcept C49105822 @default.
- W1539403786 hasConcept C530470458 @default.
- W1539403786 hasConcept C54355233 @default.
- W1539403786 hasConcept C86803240 @default.
- W1539403786 hasConcept C90583042 @default.
- W1539403786 hasConcept C91779695 @default.
- W1539403786 hasConceptScore W1539403786C104317684 @default.
- W1539403786 hasConceptScore W1539403786C121608353 @default.
- W1539403786 hasConceptScore W1539403786C134494468 @default.
- W1539403786 hasConceptScore W1539403786C2780427987 @default.
- W1539403786 hasConceptScore W1539403786C2781188995 @default.
- W1539403786 hasConceptScore W1539403786C49105822 @default.
- W1539403786 hasConceptScore W1539403786C530470458 @default.
- W1539403786 hasConceptScore W1539403786C54355233 @default.
- W1539403786 hasConceptScore W1539403786C86803240 @default.
- W1539403786 hasConceptScore W1539403786C90583042 @default.
- W1539403786 hasConceptScore W1539403786C91779695 @default.
- W1539403786 hasIssue "3" @default.
- W1539403786 hasLocation W15394037861 @default.
- W1539403786 hasOpenAccess W1539403786 @default.
- W1539403786 hasPrimaryLocation W15394037861 @default.
- W1539403786 hasRelatedWork W1968788534 @default.
- W1539403786 hasRelatedWork W1972103684 @default.
- W1539403786 hasRelatedWork W1973690102 @default.
- W1539403786 hasRelatedWork W1980223679 @default.
- W1539403786 hasRelatedWork W2004935367 @default.
- W1539403786 hasRelatedWork W2019738273 @default.
- W1539403786 hasRelatedWork W2029058389 @default.
- W1539403786 hasRelatedWork W2030093162 @default.
- W1539403786 hasRelatedWork W2036546668 @default.
- W1539403786 hasRelatedWork W2054605948 @default.
- W1539403786 hasRelatedWork W2058064521 @default.
- W1539403786 hasRelatedWork W2090740451 @default.
- W1539403786 hasRelatedWork W2103970959 @default.
- W1539403786 hasRelatedWork W2109465247 @default.
- W1539403786 hasRelatedWork W2136236200 @default.
- W1539403786 hasRelatedWork W2153579158 @default.
- W1539403786 hasRelatedWork W2340244792 @default.
- W1539403786 hasRelatedWork W2772971838 @default.
- W1539403786 hasRelatedWork W90103378 @default.
- W1539403786 hasRelatedWork W2163434396 @default.
- W1539403786 hasVolume "58" @default.
- W1539403786 isParatext "false" @default.
- W1539403786 isRetracted "false" @default.
- W1539403786 magId "1539403786" @default.
- W1539403786 workType "article" @default.