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- W153945483 abstract "Abstract Hypopituitarism is defined as the deficiency of one or more of the anterior pituitary hormones: growth hormone, thyroid stimulating hormone, lutenizing hormone, follicle stimulating hormone, prolactin, and adrenocorticotrophic hormone. The deficiency of posterior pituitary hormones, specifically antidiuretic hormone, may also be present. Hypopituitarism is often a sequela of a previous neurological insult; however, many cases are considered idiopathic. The development of the pituitary gland has been shown to be a balanced and orchestrated sequence of events dependent on the temporal and spatial appearance of multiple developmental factors that will eventually produce specific pituitary cell types. A disruption in this cascade that leads to the decreased expression of one or more of these factors results in idiopathic hypopituitarism. The identification of proteins responsible for the development of the anterior pituitary gland and their genetic alterations has provided novel insights into the mechanisms responsible for hypopituitarism. Murine models, as well as patients with hypopituitarism due to specific mutations in these developmental proteins, have assisted in the elucidation of mechanisms leading to decreased pituitary gene expression and hormone production. Furthermore, the development of more sophisticated and efficient methods for genome sequencing offers greater promise in delineating the pathogenic mechanisms in patients with idiopathic hypopituitarism." @default.
- W153945483 created "2016-06-24" @default.
- W153945483 creator A5012068391 @default.
- W153945483 creator A5070887020 @default.
- W153945483 date "2010-01-01" @default.
- W153945483 modified "2023-09-28" @default.
- W153945483 title "States of Pituitary Hypofunction" @default.
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- W153945483 doi "https://doi.org/10.1016/b978-0-12-374430-2.00007-9" @default.
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