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- W1539474059 abstract "“Haemolysin” is a generic term referring to protein toxins capable of lysing erythrocytes. The secretion of a haemolysin into the external medium by Escherichia coli (E. coli) is presented. Subsequently, both chromosomally encoded human and plasmid encoded animal uropathogenic E. coli isolates secrete haemolysin. Several determinants are subcloned from human and animal isolates including those from Proteus sp. and Actinobacillus pleuropneumoniae. The haemolysins belong to a large family of RTX toxins (repeat in toxin) that possess multiple glycine rich repeats near the C-terminus. The chapter discusses the genetic regulation and function of the E. coli haemolysin secretion system. The in vitro and in vivo role of haemolysin in pathogenesis is equally instructive, demonstrating the co-ordinate regulation of the hly operon with other pathogenic determinants and the in vitro and in vivo action of the toxin upon different cell lines. Secretion of the large 110 kDa haemolytic toxin (HlyA) by E. coli, proceeds by the so-called “Type-I secretion pathway” in Gram negative bacteria. This secretion mechanism requires the products of the four contiguous genes of the hly operon, hly C, A, B, and D." @default.
- W1539474059 created "2016-06-24" @default.
- W1539474059 creator A5046576983 @default.
- W1539474059 creator A5054429501 @default.
- W1539474059 date "1996-01-01" @default.
- W1539474059 modified "2023-09-25" @default.
- W1539474059 title "Chapter 6 Structure and function, of HlyB, the ABC-transporter essential for haemolysin secretion from escherichia coli" @default.
- W1539474059 cites W106446473 @default.
- W1539474059 cites W1468177 @default.
- W1539474059 cites W1506898213 @default.
- W1539474059 cites W1510968269 @default.
- W1539474059 cites W1525386431 @default.
- W1539474059 cites W1535422451 @default.
- W1539474059 cites W1536061423 @default.
- W1539474059 cites W1536266674 @default.
- W1539474059 cites W1554937054 @default.
- W1539474059 cites W1560299391 @default.
- W1539474059 cites W1564328218 @default.
- W1539474059 cites W1565284520 @default.
- W1539474059 cites W1579211638 @default.
- W1539474059 cites W1590138737 @default.
- W1539474059 cites W1595934517 @default.
- W1539474059 cites W161114408 @default.
- W1539474059 cites W1631248080 @default.
- W1539474059 cites W1648443176 @default.
- W1539474059 cites W1672768195 @default.
- W1539474059 cites W173588649 @default.
- W1539474059 cites W1791502820 @default.
- W1539474059 cites W180079098 @default.
- W1539474059 cites W1804694142 @default.
- W1539474059 cites W1870707005 @default.
- W1539474059 cites W1873143052 @default.
- W1539474059 cites W1892940702 @default.
- W1539474059 cites W1901894556 @default.
- W1539474059 cites W1908114653 @default.
- W1539474059 cites W1908815739 @default.
- W1539474059 cites W1920049106 @default.
- W1539474059 cites W1920054367 @default.
- W1539474059 cites W1921396112 @default.
- W1539474059 cites W1922805688 @default.
- W1539474059 cites W1923167339 @default.
- W1539474059 cites W1929171476 @default.
- W1539474059 cites W1938292149 @default.
- W1539474059 cites W1946310958 @default.
- W1539474059 cites W1956702905 @default.
- W1539474059 cites W1964817649 @default.
- W1539474059 cites W1967418034 @default.
- W1539474059 cites W1967582433 @default.
- W1539474059 cites W1968685804 @default.
- W1539474059 cites W1969490041 @default.
- W1539474059 cites W1970791807 @default.
- W1539474059 cites W1971403296 @default.
- W1539474059 cites W1975304761 @default.
- W1539474059 cites W1978530172 @default.
- W1539474059 cites W1979189272 @default.
- W1539474059 cites W1980142680 @default.
- W1539474059 cites W1983483451 @default.
- W1539474059 cites W1985672531 @default.
- W1539474059 cites W1986729024 @default.
- W1539474059 cites W1988363233 @default.
- W1539474059 cites W1989723875 @default.
- W1539474059 cites W1989820897 @default.
- W1539474059 cites W1990996770 @default.
- W1539474059 cites W1993213855 @default.
- W1539474059 cites W1994774830 @default.
- W1539474059 cites W1996072101 @default.
- W1539474059 cites W2000677962 @default.
- W1539474059 cites W200150506 @default.
- W1539474059 cites W2001889000 @default.
- W1539474059 cites W2002547333 @default.
- W1539474059 cites W2004244494 @default.
- W1539474059 cites W2011144003 @default.
- W1539474059 cites W2012891427 @default.
- W1539474059 cites W2016565590 @default.
- W1539474059 cites W2019358271 @default.
- W1539474059 cites W2019853549 @default.
- W1539474059 cites W2020694586 @default.
- W1539474059 cites W2021793865 @default.
- W1539474059 cites W2022950368 @default.
- W1539474059 cites W2026582002 @default.
- W1539474059 cites W2031374555 @default.
- W1539474059 cites W2034048814 @default.
- W1539474059 cites W2034545694 @default.
- W1539474059 cites W2036685307 @default.
- W1539474059 cites W2039358467 @default.
- W1539474059 cites W2039774419 @default.
- W1539474059 cites W2041703527 @default.
- W1539474059 cites W2044184104 @default.
- W1539474059 cites W2045206046 @default.
- W1539474059 cites W2045352920 @default.
- W1539474059 cites W2047800675 @default.
- W1539474059 cites W2048671274 @default.
- W1539474059 cites W2050236546 @default.
- W1539474059 cites W2050292589 @default.
- W1539474059 cites W2050573110 @default.
- W1539474059 cites W2053152876 @default.
- W1539474059 cites W2056613088 @default.
- W1539474059 cites W2061682297 @default.