FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539488492> ?p ?o ?g. }

• W1539488492 endingPage "1338" @default.
• W1539488492 startingPage "1329" @default.
• W1539488492 abstract "Activation of CD4(+) Th cells requires their cognate interaction with APCs bearing specific relevant MHC class II-peptide complexes. This cognate interaction culminates in the formation of an immunological synapse that contains the various proteins and lipids required for efficient T cell activation. We now show that APC lipid raft membrane microdomains contain specific class II-peptide complexes and serve as platforms that deliver these raft-associated class II molecules to the immunological synapse. APC rafts are required for T cell:APC conjugate formation and T cell activation at low densities of relevant class II-peptide complexes, a requirement that can be overcome at high class II-peptide density. Analysis of confocal microscopy images revealed that over time APC lipid rafts, raft-associated relevant class II-peptide complexes, and even immunologically irrelevant class II molecules accumulate at the immunological synapse. As the immunological synapse matures, relevant class II-peptide complexes are sorted to a central region of the interface, while irrelevant class II molecules are excluded from this site. We propose that T cell activation is facilitated by recruitment of MHC class II-peptide complexes to the immunological synapse by virtue of their constitutive association with lipid raft microdomains." @default.
• W1539488492 created "2016-06-24" @default.
• W1539488492 creator A5029421637 @default.
• W1539488492 creator A5035444874 @default.
• W1539488492 creator A5067186168 @default.
• W1539488492 date "2003-02-01" @default.
• W1539488492 modified "2023-10-12" @default.
• W1539488492 title "MHC Class II-Peptide Complexes and APC Lipid Rafts Accumulate at the Immunological Synapse" @default.
• W1539488492 cites W1503369148 @default.
• W1539488492 cites W1562441478 @default.
• W1539488492 cites W1564861448 @default.
• W1539488492 cites W1576944993 @default.
• W1539488492 cites W1635401440 @default.
• W1539488492 cites W1784927340 @default.
• W1539488492 cites W1909242640 @default.
• W1539488492 cites W1948784018 @default.
• W1539488492 cites W1968463439 @default.
• W1539488492 cites W1972145067 @default.
• W1539488492 cites W1973730600 @default.
• W1539488492 cites W1988530230 @default.
• W1539488492 cites W1989531550 @default.
• W1539488492 cites W1997507341 @default.
• W1539488492 cites W1999436383 @default.
• W1539488492 cites W2003337014 @default.
• W1539488492 cites W2005593944 @default.
• W1539488492 cites W2014310021 @default.
• W1539488492 cites W2020795276 @default.
• W1539488492 cites W2021211941 @default.
• W1539488492 cites W2024957425 @default.
• W1539488492 cites W2028968136 @default.
• W1539488492 cites W2036377994 @default.
• W1539488492 cites W2042704418 @default.
• W1539488492 cites W2043762044 @default.
• W1539488492 cites W2043893491 @default.
• W1539488492 cites W2047784800 @default.
• W1539488492 cites W2060930274 @default.
• W1539488492 cites W2062619192 @default.
• W1539488492 cites W2067006556 @default.
• W1539488492 cites W2068504553 @default.
• W1539488492 cites W2079515412 @default.
• W1539488492 cites W2086358590 @default.
• W1539488492 cites W2094525699 @default.
• W1539488492 cites W2094854776 @default.
• W1539488492 cites W2096234619 @default.
• W1539488492 cites W2115037258 @default.
• W1539488492 cites W2116364705 @default.
• W1539488492 cites W2121936687 @default.
• W1539488492 cites W2136259733 @default.
• W1539488492 cites W2138059603 @default.
• W1539488492 cites W2139846514 @default.
• W1539488492 cites W2147196312 @default.
• W1539488492 cites W2150769903 @default.
• W1539488492 doi "https://doi.org/10.4049/jimmunol.170.3.1329" @default.
• W1539488492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12538693" @default.
• W1539488492 hasPublicationYear "2003" @default.
• W1539488492 type Work @default.
• W1539488492 sameAs 1539488492 @default.
• W1539488492 citedByCount "126" @default.
• W1539488492 countsByYear W15394884922012 @default.
• W1539488492 countsByYear W15394884922013 @default.
• W1539488492 countsByYear W15394884922014 @default.
• W1539488492 countsByYear W15394884922015 @default.
• W1539488492 countsByYear W15394884922016 @default.
• W1539488492 countsByYear W15394884922017 @default.
• W1539488492 countsByYear W15394884922018 @default.
• W1539488492 countsByYear W15394884922019 @default.
• W1539488492 countsByYear W15394884922020 @default.
• W1539488492 countsByYear W15394884922021 @default.
• W1539488492 countsByYear W15394884922022 @default.
• W1539488492 countsByYear W15394884922023 @default.
• W1539488492 crossrefType "journal-article" @default.
• W1539488492 hasAuthorship W1539488492A5029421637 @default.
• W1539488492 hasAuthorship W1539488492A5035444874 @default.
• W1539488492 hasAuthorship W1539488492A5067186168 @default.
• W1539488492 hasBestOaLocation W15394884921 @default.
• W1539488492 hasConcept C127445978 @default.
• W1539488492 hasConcept C147483822 @default.
• W1539488492 hasConcept C169760540 @default.
• W1539488492 hasConcept C170627219 @default.
• W1539488492 hasConcept C185592680 @default.
• W1539488492 hasConcept C19317047 @default.
• W1539488492 hasConcept C197695756 @default.
• W1539488492 hasConcept C203014093 @default.
• W1539488492 hasConcept C207936829 @default.
• W1539488492 hasConcept C2776090121 @default.
• W1539488492 hasConcept C2778814158 @default.
• W1539488492 hasConcept C2779281246 @default.
• W1539488492 hasConcept C55493867 @default.
• W1539488492 hasConcept C62478195 @default.
• W1539488492 hasConcept C79266657 @default.
• W1539488492 hasConcept C86803240 @default.
• W1539488492 hasConcept C8891405 @default.
• W1539488492 hasConcept C95444343 @default.
• W1539488492 hasConcept C9756297 @default.
• W1539488492 hasConceptScore W1539488492C127445978 @default.
• W1539488492 hasConceptScore W1539488492C147483822 @default.
• W1539488492 hasConceptScore W1539488492C169760540 @default.
• W1539488492 hasConceptScore W1539488492C170627219 @default.

• next