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- W1539494224 abstract "Osteoarthritis (OA) is the most common cause of arthritis worldwide and represents a significant healthcare burden, particularly in the context of an ageing population. Traditionally, painkillers, injections and physiotherapy have been the mainstay of treatment, with patients being referred for joint replacement surgery (arthroplasty) when these options fail. Whilst effective in reducing pain and improving joint function, these approaches are not without potential complications. With the development of tissue-engineering techniques over recent years there has been considerable interest in applying these strategies to provide new, innovative, alternative effective means of treating OA. This review explores the unique microenvironment present within an osteoarthritic joint, highlighting the features that comprise the osteoarthritic niche and could be modulated in the development of novel treatments for OA. Existing tissue-engineering strategies for repairing bone and cartilage defects are discussed, with particular reference to how these might be modified, both to improve existing treatments, such as impaction bone grafting, as well as in the development of future treatments for OA. Copyright © 2012 John Wiley & Sons, Ltd." @default.
- W1539494224 created "2016-06-24" @default.
- W1539494224 creator A5001049383 @default.
- W1539494224 creator A5047815768 @default.
- W1539494224 creator A5050887535 @default.
- W1539494224 creator A5086010333 @default.
- W1539494224 date "2012-04-09" @default.
- W1539494224 modified "2023-09-23" @default.
- W1539494224 title "The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine" @default.
- W1539494224 cites W1505671001 @default.
- W1539494224 cites W1508246447 @default.
- W1539494224 cites W1533174836 @default.
- W1539494224 cites W1544189777 @default.
- W1539494224 cites W155856802 @default.
- W1539494224 cites W1597786401 @default.
- W1539494224 cites W1828387313 @default.
- W1539494224 cites W1895332364 @default.
- W1539494224 cites W1896485613 @default.
- W1539494224 cites W1966171234 @default.
- W1539494224 cites W1970185250 @default.
- W1539494224 cites W1970850706 @default.
- W1539494224 cites W1970968225 @default.
- W1539494224 cites W1971211678 @default.
- W1539494224 cites W1972426822 @default.
- W1539494224 cites W1972510936 @default.
- W1539494224 cites W1975417202 @default.
- W1539494224 cites W1975903829 @default.
- W1539494224 cites W1978640618 @default.
- W1539494224 cites W1981351737 @default.
- W1539494224 cites W1982589867 @default.
- W1539494224 cites W1983329739 @default.
- W1539494224 cites W1983384717 @default.
- W1539494224 cites W1983672930 @default.
- W1539494224 cites W1985735551 @default.
- W1539494224 cites W1985751488 @default.
- W1539494224 cites W1987935808 @default.
- W1539494224 cites W1988760613 @default.
- W1539494224 cites W1992252990 @default.
- W1539494224 cites W1992286141 @default.
- W1539494224 cites W1995229645 @default.
- W1539494224 cites W1996144339 @default.
- W1539494224 cites W1997957358 @default.
- W1539494224 cites W1998111995 @default.
- W1539494224 cites W1998559371 @default.
- W1539494224 cites W1999930817 @default.
- W1539494224 cites W2001229337 @default.
- W1539494224 cites W2001790670 @default.
- W1539494224 cites W2001856721 @default.
- W1539494224 cites W2003678590 @default.
- W1539494224 cites W2005832407 @default.
- W1539494224 cites W2007009331 @default.
- W1539494224 cites W2008242453 @default.
- W1539494224 cites W2008596857 @default.
- W1539494224 cites W2009096083 @default.
- W1539494224 cites W2009627812 @default.
- W1539494224 cites W2011693143 @default.
- W1539494224 cites W2014619166 @default.
- W1539494224 cites W2015073667 @default.
- W1539494224 cites W2015280480 @default.
- W1539494224 cites W2016794473 @default.
- W1539494224 cites W2016892864 @default.
- W1539494224 cites W2017268676 @default.
- W1539494224 cites W2018428699 @default.
- W1539494224 cites W2020183210 @default.
- W1539494224 cites W2020234527 @default.
- W1539494224 cites W2020975979 @default.
- W1539494224 cites W2021164682 @default.
- W1539494224 cites W2022346732 @default.
- W1539494224 cites W2022640830 @default.
- W1539494224 cites W2022783020 @default.
- W1539494224 cites W2023592016 @default.
- W1539494224 cites W2025863821 @default.
- W1539494224 cites W2026387061 @default.
- W1539494224 cites W2028880405 @default.
- W1539494224 cites W2029355740 @default.
- W1539494224 cites W2031789113 @default.
- W1539494224 cites W2032988614 @default.
- W1539494224 cites W2033514910 @default.
- W1539494224 cites W2034174652 @default.
- W1539494224 cites W2034659824 @default.
- W1539494224 cites W2036317377 @default.
- W1539494224 cites W2037362758 @default.
- W1539494224 cites W2038134163 @default.
- W1539494224 cites W2038773696 @default.
- W1539494224 cites W2038965450 @default.
- W1539494224 cites W2040253554 @default.
- W1539494224 cites W2040471298 @default.
- W1539494224 cites W2040553138 @default.
- W1539494224 cites W2043612827 @default.
- W1539494224 cites W2044764337 @default.
- W1539494224 cites W2045361446 @default.
- W1539494224 cites W2047560789 @default.
- W1539494224 cites W2048839510 @default.
- W1539494224 cites W2049140021 @default.
- W1539494224 cites W2049401592 @default.
- W1539494224 cites W2053016699 @default.
- W1539494224 cites W2054060040 @default.
- W1539494224 cites W2054495476 @default.