Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539520316> ?p ?o ?g. }
- W1539520316 endingPage "2307" @default.
- W1539520316 startingPage "2295" @default.
- W1539520316 abstract "Most mouse models of hepatocellular carcinoma have expressed growth factors and oncogenes under the control of a liver-specific promoter. In contrast, we describe here the formation of liver tumors in transgenic mice overexpressing human fibroblast growth factor 19 (FGF19) in skeletal muscle. FGF19 transgenic mice had elevated hepatic alpha-fetoprotein mRNA as early as 2 months of age, and hepatocellular carcinomas were evident by 10 months of age. Increased proliferation of pericentral hepatocytes was demonstrated by 5-bromo-2'-deoxyuridine incorporation in the FGF19 transgenic mice before tumor formation and in nontransgenic mice injected with recombinant FGF19 protein. Areas of small cell dysplasia were initially evident pericentrally, and dysplastic/neoplastic foci throughout the hepatic lobule were glutamine synthetase-positive, suggestive of a pericentral origin. Consistent with chronic activation of the Wingless/Wnt pathway, 44% of the hepatocellular tumors from FGF19 transgenic mice had nuclear staining for beta-catenin. Sequencing of the tumor DNA encoding beta-catenin revealed point mutations that resulted in amino acid substitutions. These findings suggest a previously unknown role for FGF19 in hepatocellular carcinomas." @default.
- W1539520316 created "2016-06-24" @default.
- W1539520316 creator A5010721531 @default.
- W1539520316 creator A5015348553 @default.
- W1539520316 creator A5037207107 @default.
- W1539520316 creator A5039233915 @default.
- W1539520316 creator A5040139978 @default.
- W1539520316 creator A5062527322 @default.
- W1539520316 creator A5064150623 @default.
- W1539520316 creator A5064330604 @default.
- W1539520316 creator A5075113585 @default.
- W1539520316 creator A5077639382 @default.
- W1539520316 creator A5078515865 @default.
- W1539520316 creator A5079200349 @default.
- W1539520316 creator A5088520741 @default.
- W1539520316 date "2002-06-01" @default.
- W1539520316 modified "2023-10-04" @default.
- W1539520316 title "A Mouse Model of Hepatocellular Carcinoma" @default.
- W1539520316 cites W1483574195 @default.
- W1539520316 cites W1529442571 @default.
- W1539520316 cites W1541491219 @default.
- W1539520316 cites W1595643096 @default.
- W1539520316 cites W170157502 @default.
- W1539520316 cites W1895661015 @default.
- W1539520316 cites W1924015987 @default.
- W1539520316 cites W1966737159 @default.
- W1539520316 cites W1972121945 @default.
- W1539520316 cites W1974911740 @default.
- W1539520316 cites W1977556462 @default.
- W1539520316 cites W1982882974 @default.
- W1539520316 cites W1987580232 @default.
- W1539520316 cites W1988191963 @default.
- W1539520316 cites W1990563353 @default.
- W1539520316 cites W1991355519 @default.
- W1539520316 cites W1992787804 @default.
- W1539520316 cites W2000380740 @default.
- W1539520316 cites W2012039807 @default.
- W1539520316 cites W2024668373 @default.
- W1539520316 cites W2027962951 @default.
- W1539520316 cites W2030500412 @default.
- W1539520316 cites W2039713619 @default.
- W1539520316 cites W2042055907 @default.
- W1539520316 cites W2046034941 @default.
- W1539520316 cites W2058704935 @default.
- W1539520316 cites W2059072983 @default.
- W1539520316 cites W2062911730 @default.
- W1539520316 cites W2064109640 @default.
- W1539520316 cites W2070448070 @default.
- W1539520316 cites W2075487664 @default.
- W1539520316 cites W2076406046 @default.
- W1539520316 cites W2076684492 @default.
- W1539520316 cites W2081985759 @default.
- W1539520316 cites W2085867188 @default.
- W1539520316 cites W2086889008 @default.
- W1539520316 cites W2090485483 @default.
- W1539520316 cites W2095971990 @default.
- W1539520316 cites W2101125191 @default.
- W1539520316 cites W2106986971 @default.
- W1539520316 cites W2108361166 @default.
- W1539520316 cites W2110722896 @default.
- W1539520316 cites W2115125970 @default.
- W1539520316 cites W2118688616 @default.
- W1539520316 cites W2121046480 @default.
- W1539520316 cites W2122892477 @default.
- W1539520316 cites W2128337755 @default.
- W1539520316 cites W2142466677 @default.
- W1539520316 cites W2144300167 @default.
- W1539520316 cites W2151953516 @default.
- W1539520316 cites W2172134989 @default.
- W1539520316 cites W21751534 @default.
- W1539520316 cites W2308806306 @default.
- W1539520316 cites W2316712853 @default.
- W1539520316 cites W2327039673 @default.
- W1539520316 cites W2328982351 @default.
- W1539520316 cites W2334330269 @default.
- W1539520316 cites W2406482053 @default.
- W1539520316 cites W2412203941 @default.
- W1539520316 cites W2414822720 @default.
- W1539520316 cites W2415561223 @default.
- W1539520316 cites W2418460613 @default.
- W1539520316 cites W314826190 @default.
- W1539520316 cites W4235325062 @default.
- W1539520316 cites W4237329722 @default.
- W1539520316 cites W4322371250 @default.
- W1539520316 cites W69362276 @default.
- W1539520316 doi "https://doi.org/10.1016/s0002-9440(10)61177-7" @default.
- W1539520316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850847" @default.
- W1539520316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12057932" @default.
- W1539520316 hasPublicationYear "2002" @default.
- W1539520316 type Work @default.
- W1539520316 sameAs 1539520316 @default.
- W1539520316 citedByCount "314" @default.
- W1539520316 countsByYear W15395203162012 @default.
- W1539520316 countsByYear W15395203162013 @default.
- W1539520316 countsByYear W15395203162014 @default.
- W1539520316 countsByYear W15395203162015 @default.
- W1539520316 countsByYear W15395203162016 @default.
- W1539520316 countsByYear W15395203162017 @default.