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- W1539591862 abstract "This chapter discusses the yeast S. cerevisiae that is a useful host to study the mechanism of action of P-glycoprotein (Pgp) and identifies structure–function relationships in this protein. Pgp expressed in yeast cells has conserved functional characteristics established for this protein in mammalian cells. Individual Pgp mutants can be expressed and characterized in yeast in a relatively rapid and inexpensive fashion, facilitating the high-throughput analysis of a large number of individual mutants. Yeast can be used for additional genetic analysis of Pgp, including the selection of intragenic suppressors of null mutations in Pgp, an analysis virtually impossible to carry out in mammalian cells. Yeast seems to be a suitable host for other members of the ATP-binding cassette (ABC) transporters family because the human MRP protein and the pfrndr1 gene product of Plasmodium falciparum are expressed in yeast." @default.
- W1539591862 created "2016-06-24" @default.
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- W1539591862 date "1998-01-01" @default.
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- W1539591862 title "[30] Mutational analysis of P-glycoprotein in yeast Saccharomyces cerevisiae" @default.
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- W1539591862 doi "https://doi.org/10.1016/s0076-6879(98)92032-8" @default.
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