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• W1539606768 abstract "Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti‐inflammatory, anti‐carcinogenic and anti‐bacterial properties. This study was designed to investigate the anti‐inflammatory effects of CAPE on Helicobacter pylori ‐induced NF‐ κ B and AP‐1 in the gastric epithelial cell line AGS. Electrophoretic mobility shift assay was used to measure NF‐ κ B‐ and AP‐1‐DNA binding activity. Western blotting was used to detect I κ B‐ α and COX‐2 expression in AGS cells cocultured with H. pylori . The antiproliferative effect of CAPE was measured by MTT assay. Our results showed that caffeic phenethyl ester inhibits H. pylori ‐induced NF‐ κ B and AP‐1 DNA‐binding activity in a dose (0.1–25 μ g ml −1 ∼0.35–88 μ M ) and time‐ (15–240 min) dependent manner in AGS cells. Maximum inhibition by CAPE was observed at concentrations of 25 μ g ml −1 (∼88 μ M ) CAPE prevented H. pylori ‐ and cytokine‐induced degradation of I κ B‐ α protein. Pretreatment of AGS cells with CAPE also blocked cytokine‐ and mitogen‐induced NF‐ κ B and AP‐1 expression. Furthermore, CAPE suppressed H. pylori ‐induced cell proliferation and production of the cytokines TNF‐ α and IL‐8. In addition, CAPE blocked H. pylori ‐induced COX‐2 expression. The inhibition of such transcription by CAPE could result in suppression of many genes during H. pylori ‐induced inflammation, and also provide new insights into the anti‐cancer and anti‐inflammatory properties of CAPE. British Journal of Pharmacology (2005) 146 , 1139–1147. doi: 10.1038/sj.bjp.0706421" @default.
• W1539606768 created "2016-06-24" @default.
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• W1539606768 date "2005-12-01" @default.
• W1539606768 modified "2023-10-13" @default.
• W1539606768 title "Caffeic acid phenethyl ester modulates<i>Helicobacter pylori</i>-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells" @default.
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• W1539606768 doi "https://doi.org/10.1038/sj.bjp.0706421" @default.
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