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- W1539681903 abstract "Objectives:- To evaluate myocardial tissue characterisation by cardiovascular magnetic resonance (CMR) to predict functional recovery in reperfused acute myocardial infarction (AMI).Background:-Prognosis following AMI is closely related to recovery of myocardial contractile function. Accurate early prediction of functional recovery may allow for additional therapies in high risk patients, and avoid over-treatment of lower risk patients. Clinical prognostication commonly relies on echocardiographic evaluation of function, which may be misleading acutely. CMR offers a number of ways to refine prediction of functional recovery by characterising myocardial tissue, but these have not been extensively evaluated.Methods:-Patients following reperfusion for first-presentation ST-elevation AMI were scanned by CMR acutely, subacutely and in convalescence. Tissue pathologies visible on acute CMR were evaluated for their ability to predict recovery of contractile function. Oedema in the peri-infarct zone, microvascular obstruction (MO) and intramyocardial haemorrhage (IMH) in the infarct zone, and extracellular volume (ECV) of the infarct zone were evaluated. In addition, susceptibility-weighted MR imaging (SW-MRI) was evaluated against the reference standards of T2-weighted and T2* imaging to detect the known prognostic marker of IMH.Results:-Acutely oedematous myocardium demonstrated recovery of function over time (p 0.05). Recovery of function closely mirrored resolution of oedema. Infarct contractile recovery was attenuated in infarcts that demonstrated MO acutely as compared to those without (p<0.01), and attenuated further in those that demonstrated IMH acutely (p<0.01). SW-MRI had sensitivity 93% and specificity 86% as compared to T2-weighted imaging, with excellent inter-observer reliability and shorter breath-hold times (4 seconds vs. 16 seconds). Infarct ECV had higher accuracy to predict improved wall motion than late gadolinium enhancement imaging (c-statistic 0.80 vs. 0.70, p=0.04).Conclusion:-Tissue characterisation by CMR offers a variety of ways to predict functional outcome following AMI, using both established and novel imaging techniques." @default.
- W1539681903 created "2016-06-24" @default.
- W1539681903 creator A5085466308 @default.
- W1539681903 date "2014-09-01" @default.
- W1539681903 modified "2023-09-22" @default.
- W1539681903 title "Myocardial tissue characterisation and functional assessment by magnetic resonance imaging in ST elevation myocardial infarction" @default.
- W1539681903 cites W111458436 @default.
- W1539681903 cites W118182295 @default.
- W1539681903 cites W127633853 @default.
- W1539681903 cites W150005071 @default.
- W1539681903 cites W1514303257 @default.
- W1539681903 cites W1566670098 @default.
- W1539681903 cites W1608068076 @default.
- W1539681903 cites W1630602822 @default.
- W1539681903 cites W181211916 @default.
- W1539681903 cites W181422202 @default.
- W1539681903 cites W188573093 @default.
- W1539681903 cites W1896651977 @default.
- W1539681903 cites W1931160891 @default.
- W1539681903 cites W1934994215 @default.
- W1539681903 cites W1964347199 @default.
- W1539681903 cites W1964765606 @default.
- W1539681903 cites W1964906439 @default.
- W1539681903 cites W1965116809 @default.
- W1539681903 cites W1965951694 @default.
- W1539681903 cites W1967100598 @default.
- W1539681903 cites W1968286219 @default.
- W1539681903 cites W1968444051 @default.
- W1539681903 cites W1968813434 @default.
- W1539681903 cites W1972144072 @default.
- W1539681903 cites W1972592277 @default.
- W1539681903 cites W1972610891 @default.
- W1539681903 cites W1972911377 @default.
- W1539681903 cites W1973760359 @default.
- W1539681903 cites W1974718993 @default.
- W1539681903 cites W1977154683 @default.
- W1539681903 cites W1977423202 @default.
- W1539681903 cites W1977606374 @default.
- W1539681903 cites W1977895321 @default.
- W1539681903 cites W1978145432 @default.
- W1539681903 cites W1979258496 @default.
- W1539681903 cites W1979576695 @default.
- W1539681903 cites W1980189046 @default.
- W1539681903 cites W1981080292 @default.
- W1539681903 cites W1981311540 @default.
- W1539681903 cites W1981567283 @default.
- W1539681903 cites W1982826647 @default.
- W1539681903 cites W1983068708 @default.
- W1539681903 cites W1983374780 @default.
- W1539681903 cites W1985882242 @default.
- W1539681903 cites W1986224413 @default.
- W1539681903 cites W1986622667 @default.
- W1539681903 cites W1987651688 @default.
- W1539681903 cites W1987676379 @default.
- W1539681903 cites W1990224341 @default.
- W1539681903 cites W1991075316 @default.
- W1539681903 cites W1993293116 @default.
- W1539681903 cites W199458551 @default.
- W1539681903 cites W1995485664 @default.
- W1539681903 cites W1996704811 @default.
- W1539681903 cites W1997201105 @default.
- W1539681903 cites W1999538891 @default.
- W1539681903 cites W2000356219 @default.
- W1539681903 cites W2003447766 @default.
- W1539681903 cites W2004472601 @default.
- W1539681903 cites W2004985101 @default.
- W1539681903 cites W2005914358 @default.
- W1539681903 cites W2006939676 @default.
- W1539681903 cites W2008188455 @default.
- W1539681903 cites W2008311622 @default.
- W1539681903 cites W2010194853 @default.
- W1539681903 cites W2012633585 @default.
- W1539681903 cites W2013104291 @default.
- W1539681903 cites W2016175714 @default.
- W1539681903 cites W2018306237 @default.
- W1539681903 cites W2018946957 @default.
- W1539681903 cites W2020642977 @default.
- W1539681903 cites W2021253052 @default.
- W1539681903 cites W2023424277 @default.
- W1539681903 cites W2023634218 @default.
- W1539681903 cites W2029830549 @default.
- W1539681903 cites W2029948050 @default.
- W1539681903 cites W2030883724 @default.
- W1539681903 cites W2032203291 @default.
- W1539681903 cites W2033858209 @default.
- W1539681903 cites W2035246484 @default.
- W1539681903 cites W2036011993 @default.
- W1539681903 cites W2036876430 @default.
- W1539681903 cites W2037325031 @default.
- W1539681903 cites W2037563659 @default.
- W1539681903 cites W2038590479 @default.
- W1539681903 cites W2039057919 @default.
- W1539681903 cites W2041793537 @default.
- W1539681903 cites W2042366423 @default.
- W1539681903 cites W2042476232 @default.
- W1539681903 cites W2043243141 @default.
- W1539681903 cites W2044389346 @default.
- W1539681903 cites W2044539175 @default.
- W1539681903 cites W2044937956 @default.
- W1539681903 cites W2047100993 @default.