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- W1539708241 abstract "Estradiol and progesterone receptor concentrations were determined in cytoplasmic and nuclear fractions of endometrial cancer specimens taken from 43 postmenopausal women. In addition to receptors, ornithine decarboxylase and 17β-estradiol hydroxysteroid dehydrogenase activities were also measured before and after antiestrogen treatment to evaluate hormone sensitivity of the tumors. Fifteen patients received tamoxifen p.o. (40 mg daily for 5 to 7 days; Group 1) and 10 patients ingested 10 mg of tamoxifen 8 and 4 hr prior to a second endometrial sampling (Group 2).All tumors except one contained variable (often large) amounts of total estradiol receptors (mean, ∼1.8 pmol/mg DNA) in the range of those observed in the late proliferative phase of the cycle. The total progesterone receptor concentration (mean, ∼1.5 pmol/mg DNA) was in the range of the late secretory phase and was considered undetectable or insignificant (<0.3 pmol/mg DNA) in 10 cases. Although higher levels of receptors were observed in well-differentiated cancers, no significant correlation was found between receptor concentrations and histological grading. Both receptors concentrated primarily in the cytoplasm. However, in 11 and 5 cases, respectively, the majority of estradiol and progesterone receptors were located in the nuclei.Following tamoxifen administration, progesterone receptor concentrations in Group 1 increased significantly ( p < 0.05), but ornithine decarboxylase activity did not. Because tamoxifen may have induced a rapid and transitory increase of enzyme activity, ornithine decarboxylase was studied in Group 2 patients. Again no change in the enzyme activity was observed. Progesterone recpetor did not vary, but nuclear estradiol receptor increased, indicating the tamoxifen effectiveness. No meaningful changes occurred in 17β-estradiol hydroxysteroid dehydrogenase activities in either group.Estrone, estradiol, and progesterone were also measured in serum. Mean estrone values [33.8 ± 2.5 (S.E.) pg/ml] were greater than mean estradiol concentrations (23.6 ± 5 pg/ml). Estrone values increased significantly ( p < 0.01) from well- to less-differentiated tumors in relation to body weight, whereas progesterone (<1 ng/ml) and estradiol concentrations did not. All steroid concentrations were unchanged after tamoxifen.We conclude that ( a ) measurements of both cytoplasmic and nuclear receptors are necessary to accurately report receptor concentrations; ( b ) further trial with tamoxifen challenge test is justified to predict hormone responsiveness; and ( c ) this antiestrogen may become an important component in the treatment of advanced or metastatic endometrial carcinoma." @default.
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- W1539708241 date "1981-03-01" @default.
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- W1539708241 title "Female sex steroid receptors in postmenopausal endometrial carcinoma and biochemical response to an antiestrogen." @default.
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