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• W1539741413 endingPage "6072" @default.
• W1539741413 startingPage "6065" @default.
• W1539741413 abstract "Following activation with proliferative stimuli, including ligation of CD40, dense human tonsillar B cells (>98% cells in G(0)) have increased cleavage and activation of caspase-8 and -6 accompanied by decreased caspase-3 activation and apoptosis. Proliferation was blocked by either a broad specificity caspase inhibitor or inhibitors selective for caspase-6 or caspase-8. In contrast, an inhibitor selective for caspase-3 was without effect. Furthermore, induction of cyclin D and cyclin-dependent kinase 4 mRNA and protein was blocked upon inhibition of caspase-6, but not caspase-3. Thus, caspase-6-like activity is required for quiescent B cells to increase the expression of genes required for entry into G(1). In support of this model, the transcriptional suppressor special AT-rich sequence-binding protein 1, a preferred caspase-6 substrate, was cleaved upon B cell stimulation. Caspase activity was not required for all signaling events, as caspase inhibitors did not affect the phosphorylation of p42/44 mitogen-activated protein kinase, the expression of the survival factor cellular inhibitor of apoptosis 2, or the production of IL-6 by stimulated G(0) B cells. These findings suggest a mechanism by which caspase-6 may selectively allow entry of quiescent B cells into the cell cycle." @default.
• W1539741413 created "2016-06-24" @default.
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• W1539741413 date "2003-06-15" @default.
• W1539741413 modified "2023-09-23" @default.
• W1539741413 title "Caspase Activity Is Required for Stimulated B Lymphocytes to Enter the Cell Cycle" @default.
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• W1539741413 doi "https://doi.org/10.4049/jimmunol.170.12.6065" @default.
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