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• W1539776265 abstract "Intracerebral inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in a chronic, immunologically mediated demyelinating disease that shares many features with human multiple sclerosis. CD4+ T lymphocytes play a critical role in the pathogenesis of virus-induced demyelinating disease. We have identified a region within amino acid residues 24 to 37 of the VP3 capsid protein of TMEV (VP3(24-37)) that is recognized by T lymphocytes from the demyelination-susceptible SJL/J strain of mice. The T-cell response to VP3(24-37) represents a predominant Th-cell response against the virus from either TMEV-immunized or TMEV-infected SJL/J mice, and viral epitopes VP1(233-250), VP2(74-86), and VP3(24-37) account for most of the Th-cell response to TMEV." @default.
• W1539776265 created "2016-06-24" @default.
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• W1539776265 date "1995-11-01" @default.
• W1539776265 modified "2023-09-25" @default.
• W1539776265 title "Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice" @default.
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• W1539776265 doi "https://doi.org/10.1128/jvi.69.11.7315-7318.1995" @default.
• W1539776265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189661" @default.
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