FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539897961> ?p ?o ?g. }

• W1539897961 endingPage "2658" @default.
• W1539897961 startingPage "2650" @default.
• W1539897961 abstract "Helicobacter pylori colonization of the stomach affects about half of the world population and is associated with the development of gastritis, ulcers, and cancer. Polymorphisms in the IL1B gene are linked to an increased risk of H. pylori associated cancer, but the bacterial and host factors that regulate interleukin (IL)-1β production in response to H. pylori infection remain unknown. Using murine BM-derived DCs, we show that the bacterial virulence factors cytotoxin-associated genes pathogenicity island and CagL, but not vacuolating cytotoxin A or CagA, regulate the induction of pro-IL-1β and the production of mature IL-1β in response to H. pylori infection. We further show that the host receptors, Toll-like receptor 2 (TLR2) and nucleotide-binding oligomerization domain 2 (NOD2), but not NOD1, are required for induction of pro-IL-1β and NOD-like receptor pyrin domain containing 3 (NLRP3) in H. pylori infected DCs. In contrast, NLRP3 and the adaptor ASC were essential for the activation of caspase-1, processing of pro-IL-1β into IL-1β, and IL-1β secretion. Finally, we show that mice deficient in caspase-1, IL-1β, and IL-1 receptor, but not NLRP3, are impaired in the clearance of CagA-positive H. pylori from the stomach when compared with WT mice. These studies identify bacterial cag pathogenicity island and the cooperative interaction among host innate receptors TLR2, NOD2, and NLRP3 as important regulators of IL-1β production in H. pylori infected DCs." @default.
• W1539897961 created "2016-06-24" @default.
• W1539897961 creator A5040117830 @default.
• W1539897961 creator A5056524563 @default.
• W1539897961 creator A5058468655 @default.
• W1539897961 creator A5058538828 @default.
• W1539897961 creator A5080898957 @default.
• W1539897961 date "2013-07-25" @default.
• W1539897961 modified "2023-10-17" @default.
• W1539897961 title "The Cag pathogenicity island and interaction between <scp>TLR</scp> 2/ <scp>NOD</scp> 2 and <scp>NLRP</scp> 3 regulate <scp>IL</scp> ‐1β production in <i>Helicobacter pylori</i> infected dendritic cells" @default.
• W1539897961 cites W1580649365 @default.
• W1539897961 cites W1965254865 @default.
• W1539897961 cites W1966625479 @default.
• W1539897961 cites W1969980017 @default.
• W1539897961 cites W1980612524 @default.
• W1539897961 cites W1981837371 @default.
• W1539897961 cites W1987535382 @default.
• W1539897961 cites W1990268405 @default.
• W1539897961 cites W1992945893 @default.
• W1539897961 cites W1997986829 @default.
• W1539897961 cites W2003035812 @default.
• W1539897961 cites W2021857124 @default.
• W1539897961 cites W2022948175 @default.
• W1539897961 cites W2040024879 @default.
• W1539897961 cites W2040853949 @default.
• W1539897961 cites W2042851093 @default.
• W1539897961 cites W2046454404 @default.
• W1539897961 cites W2051658957 @default.
• W1539897961 cites W2069502810 @default.
• W1539897961 cites W2075583035 @default.
• W1539897961 cites W2077502013 @default.
• W1539897961 cites W2095495335 @default.
• W1539897961 cites W2104722369 @default.
• W1539897961 cites W2109491705 @default.
• W1539897961 cites W2109643723 @default.
• W1539897961 cites W2111900042 @default.
• W1539897961 cites W2114389121 @default.
• W1539897961 cites W2118403357 @default.
• W1539897961 cites W2125309974 @default.
• W1539897961 cites W2136736147 @default.
• W1539897961 cites W2138382422 @default.
• W1539897961 cites W2164838962 @default.
• W1539897961 cites W2169674958 @default.
• W1539897961 cites W4211217520 @default.
• W1539897961 cites W4240713772 @default.
• W1539897961 doi "https://doi.org/10.1002/eji.201243281" @default.
• W1539897961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3797179" @default.
• W1539897961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23818043" @default.
• W1539897961 hasPublicationYear "2013" @default.
• W1539897961 type Work @default.
• W1539897961 sameAs 1539897961 @default.
• W1539897961 citedByCount "119" @default.
• W1539897961 countsByYear W15398979612013 @default.
• W1539897961 countsByYear W15398979612014 @default.
• W1539897961 countsByYear W15398979612015 @default.
• W1539897961 countsByYear W15398979612016 @default.
• W1539897961 countsByYear W15398979612017 @default.
• W1539897961 countsByYear W15398979612018 @default.
• W1539897961 countsByYear W15398979612019 @default.
• W1539897961 countsByYear W15398979612020 @default.
• W1539897961 countsByYear W15398979612021 @default.
• W1539897961 countsByYear W15398979612022 @default.
• W1539897961 countsByYear W15398979612023 @default.
• W1539897961 crossrefType "journal-article" @default.
• W1539897961 hasAuthorship W1539897961A5040117830 @default.
• W1539897961 hasAuthorship W1539897961A5056524563 @default.
• W1539897961 hasAuthorship W1539897961A5058468655 @default.
• W1539897961 hasAuthorship W1539897961A5058538828 @default.
• W1539897961 hasAuthorship W1539897961A5080898957 @default.
• W1539897961 hasBestOaLocation W15398979611 @default.
• W1539897961 hasConcept C104317684 @default.
• W1539897961 hasConcept C136449434 @default.
• W1539897961 hasConcept C139174496 @default.
• W1539897961 hasConcept C170493617 @default.
• W1539897961 hasConcept C203014093 @default.
• W1539897961 hasConcept C2776070231 @default.
• W1539897961 hasConcept C2776409635 @default.
• W1539897961 hasConcept C2777209026 @default.
• W1539897961 hasConcept C2777291061 @default.
• W1539897961 hasConcept C2778204961 @default.
• W1539897961 hasConcept C2781090273 @default.
• W1539897961 hasConcept C2781236682 @default.
• W1539897961 hasConcept C54355233 @default.
• W1539897961 hasConcept C60987743 @default.
• W1539897961 hasConcept C62130838 @default.
• W1539897961 hasConcept C7573103 @default.
• W1539897961 hasConcept C86803240 @default.
• W1539897961 hasConcept C8891405 @default.
• W1539897961 hasConcept C89423630 @default.
• W1539897961 hasConceptScore W1539897961C104317684 @default.
• W1539897961 hasConceptScore W1539897961C136449434 @default.
• W1539897961 hasConceptScore W1539897961C139174496 @default.
• W1539897961 hasConceptScore W1539897961C170493617 @default.
• W1539897961 hasConceptScore W1539897961C203014093 @default.
• W1539897961 hasConceptScore W1539897961C2776070231 @default.
• W1539897961 hasConceptScore W1539897961C2776409635 @default.
• W1539897961 hasConceptScore W1539897961C2777209026 @default.
• W1539897961 hasConceptScore W1539897961C2777291061 @default.

• next