FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539950318> ?p ?o ?g. }

• W1539950318 endingPage "1290" @default.
• W1539950318 startingPage "1282" @default.
• W1539950318 abstract "Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first enzyme in the biosynthetic pathway of the branched-chain amino acids. It catalyzes the conversion of two molecules of pyruvate into 2-acetolactate or one molecule of pyruvate and one molecule of 2-ketobutyrate into 2-aceto-2-hydroxybutyrate. AHAS requires the cofactors thiamine diphosphate (ThDP), Mg(2+) and FAD for activity. The herbicides that target this enzyme are effective in protecting a broad range of crops from weed species. However, resistance in the field is now a serious problem worldwide. To address this, two new sulfonylureas, monosulfuron and monosulfuron ester, have been developed as commercial herbicides in China. These molecules differ from the traditional sulfonylureas in that the heterocyclic ring attached to the nitrogen atom of the sulfonylurea bridge is monosubstituted rather than disubstituted. The structures of these compounds in complex with the catalytic subunit of Arabidopsis thaliana AHAS have been determined to 3.0 and 2.8 A, respectively. In both complexes, these molecules are bound in the tunnel leading to the active site, such that the sole substituent of the heterocyclic ring is buried deepest and oriented towards the ThDP. Unlike the structures of Arabidopsis thaliana AHAS in complex with the classic disubstituted sulfonylureas, where ThDP is broken, this cofactor is intact and present most likely as the hydroxylethyl intermediate." @default.
• W1539950318 created "2016-06-24" @default.
• W1539950318 creator A5009516662 @default.
• W1539950318 creator A5012309357 @default.
• W1539950318 creator A5017320160 @default.
• W1539950318 creator A5079853523 @default.
• W1539950318 creator A5082787229 @default.
• W1539950318 creator A5085360734 @default.
• W1539950318 creator A5091488376 @default.
• W1539950318 date "2009-01-27" @default.
• W1539950318 modified "2023-10-10" @default.
• W1539950318 title "Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase" @default.
• W1539950318 cites W1539796472 @default.
• W1539950318 cites W1622528294 @default.
• W1539950318 cites W1970475270 @default.
• W1539950318 cites W1971898451 @default.
• W1539950318 cites W1975121238 @default.
• W1539950318 cites W1994342014 @default.
• W1539950318 cites W2018468640 @default.
• W1539950318 cites W2048100901 @default.
• W1539950318 cites W2052406702 @default.
• W1539950318 cites W2063442699 @default.
• W1539950318 cites W2063523570 @default.
• W1539950318 cites W2122661102 @default.
• W1539950318 cites W2125289895 @default.
• W1539950318 cites W2125576777 @default.
• W1539950318 cites W2136665220 @default.
• W1539950318 cites W2144081223 @default.
• W1539950318 cites W2147048827 @default.
• W1539950318 cites W2335883500 @default.
• W1539950318 cites W2950672344 @default.
• W1539950318 doi "https://doi.org/10.1111/j.1742-4658.2009.06863.x" @default.
• W1539950318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19187232" @default.
• W1539950318 hasPublicationYear "2009" @default.
• W1539950318 type Work @default.
• W1539950318 sameAs 1539950318 @default.
• W1539950318 citedByCount "50" @default.
• W1539950318 countsByYear W15399503182012 @default.
• W1539950318 countsByYear W15399503182013 @default.
• W1539950318 countsByYear W15399503182014 @default.
• W1539950318 countsByYear W15399503182015 @default.
• W1539950318 countsByYear W15399503182016 @default.
• W1539950318 countsByYear W15399503182017 @default.
• W1539950318 countsByYear W15399503182018 @default.
• W1539950318 countsByYear W15399503182019 @default.
• W1539950318 countsByYear W15399503182020 @default.
• W1539950318 countsByYear W15399503182021 @default.
• W1539950318 countsByYear W15399503182022 @default.
• W1539950318 countsByYear W15399503182023 @default.
• W1539950318 crossrefType "journal-article" @default.
• W1539950318 hasAuthorship W1539950318A5009516662 @default.
• W1539950318 hasAuthorship W1539950318A5012309357 @default.
• W1539950318 hasAuthorship W1539950318A5017320160 @default.
• W1539950318 hasAuthorship W1539950318A5079853523 @default.
• W1539950318 hasAuthorship W1539950318A5082787229 @default.
• W1539950318 hasAuthorship W1539950318A5085360734 @default.
• W1539950318 hasAuthorship W1539950318A5091488376 @default.
• W1539950318 hasConcept C104317684 @default.
• W1539950318 hasConcept C112243037 @default.
• W1539950318 hasConcept C134018914 @default.
• W1539950318 hasConcept C143065580 @default.
• W1539950318 hasConcept C181199279 @default.
• W1539950318 hasConcept C185592680 @default.
• W1539950318 hasConcept C197957613 @default.
• W1539950318 hasConcept C2775988993 @default.
• W1539950318 hasConcept C2777269803 @default.
• W1539950318 hasConcept C2778854520 @default.
• W1539950318 hasConcept C2779306644 @default.
• W1539950318 hasConcept C2779491563 @default.
• W1539950318 hasConcept C2780785311 @default.
• W1539950318 hasConcept C41183919 @default.
• W1539950318 hasConcept C55493867 @default.
• W1539950318 hasConcept C71240020 @default.
• W1539950318 hasConcept C86803240 @default.
• W1539950318 hasConceptScore W1539950318C104317684 @default.
• W1539950318 hasConceptScore W1539950318C112243037 @default.
• W1539950318 hasConceptScore W1539950318C134018914 @default.
• W1539950318 hasConceptScore W1539950318C143065580 @default.
• W1539950318 hasConceptScore W1539950318C181199279 @default.
• W1539950318 hasConceptScore W1539950318C185592680 @default.
• W1539950318 hasConceptScore W1539950318C197957613 @default.
• W1539950318 hasConceptScore W1539950318C2775988993 @default.
• W1539950318 hasConceptScore W1539950318C2777269803 @default.
• W1539950318 hasConceptScore W1539950318C2778854520 @default.
• W1539950318 hasConceptScore W1539950318C2779306644 @default.
• W1539950318 hasConceptScore W1539950318C2779491563 @default.
• W1539950318 hasConceptScore W1539950318C2780785311 @default.
• W1539950318 hasConceptScore W1539950318C41183919 @default.
• W1539950318 hasConceptScore W1539950318C55493867 @default.
• W1539950318 hasConceptScore W1539950318C71240020 @default.
• W1539950318 hasConceptScore W1539950318C86803240 @default.
• W1539950318 hasIssue "5" @default.
• W1539950318 hasLocation W15399503181 @default.
• W1539950318 hasLocation W15399503182 @default.
• W1539950318 hasOpenAccess W1539950318 @default.
• W1539950318 hasPrimaryLocation W15399503181 @default.
• W1539950318 hasRelatedWork W1624832283 @default.
• W1539950318 hasRelatedWork W1914977717 @default.

• next