Matches in SemOpenAlex for { <https://semopenalex.org/work/W1539960807> ?p ?o ?g. }
- W1539960807 endingPage "617" @default.
- W1539960807 startingPage "608" @default.
- W1539960807 abstract "G protein-coupled receptors are vital membrane proteins that allosterically transduce biomolecular signals across the cell membrane. However, the process by which ligand binding induces protein conformation changes is not well understood biophysically. Rhodopsin, the mammalian dim-light receptor, is a unique test case for understanding these processes because of its switch-like activity; the ligand, retinal, is bound throughout the activation cycle, switching from inverse agonist to agonist after absorbing a photon. By contrast, the ligand-free opsin is outside the activation cycle and may behave differently. We find that retinal influences rhodopsin dynamics using an ensemble of all-atom molecular dynamics simulations that in aggregate contain 100 μs of sampling. Active retinal destabilizes the inactive state of the receptor, whereas the active ensemble was more structurally homogenous. By contrast, simulations of an active-like receptor without retinal present were much more heterogeneous than those containing retinal. These results suggest allosteric processes are more complicated than a ligand inducing protein conformational changes or simply capturing a shifted ensemble as outlined in classic models of allostery." @default.
- W1539960807 created "2016-06-24" @default.
- W1539960807 creator A5028578960 @default.
- W1539960807 creator A5041647675 @default.
- W1539960807 creator A5062265964 @default.
- W1539960807 creator A5073891484 @default.
- W1539960807 date "2015-08-01" @default.
- W1539960807 modified "2023-09-30" @default.
- W1539960807 title "Retinal Conformation Changes Rhodopsin’s Dynamic Ensemble" @default.
- W1539960807 cites W107112169 @default.
- W1539960807 cites W1542579814 @default.
- W1539960807 cites W1595449036 @default.
- W1539960807 cites W185625864 @default.
- W1539960807 cites W1964439982 @default.
- W1539960807 cites W1968682237 @default.
- W1539960807 cites W1974030600 @default.
- W1539960807 cites W1984185958 @default.
- W1539960807 cites W1984340631 @default.
- W1539960807 cites W1989941347 @default.
- W1539960807 cites W1989971979 @default.
- W1539960807 cites W1992131445 @default.
- W1539960807 cites W1997340548 @default.
- W1539960807 cites W1997554019 @default.
- W1539960807 cites W1998273363 @default.
- W1539960807 cites W1998423869 @default.
- W1539960807 cites W2005798169 @default.
- W1539960807 cites W2007798355 @default.
- W1539960807 cites W2007898019 @default.
- W1539960807 cites W2014252415 @default.
- W1539960807 cites W2014407510 @default.
- W1539960807 cites W2016713175 @default.
- W1539960807 cites W2019948651 @default.
- W1539960807 cites W2021389305 @default.
- W1539960807 cites W2022117024 @default.
- W1539960807 cites W2024273013 @default.
- W1539960807 cites W2027408247 @default.
- W1539960807 cites W2027790571 @default.
- W1539960807 cites W2028645925 @default.
- W1539960807 cites W2030368884 @default.
- W1539960807 cites W2035687084 @default.
- W1539960807 cites W2038758364 @default.
- W1539960807 cites W2039551622 @default.
- W1539960807 cites W2041205020 @default.
- W1539960807 cites W2041566506 @default.
- W1539960807 cites W2050333027 @default.
- W1539960807 cites W2057182930 @default.
- W1539960807 cites W2059551149 @default.
- W1539960807 cites W2060319658 @default.
- W1539960807 cites W2061785801 @default.
- W1539960807 cites W2062165317 @default.
- W1539960807 cites W2066414494 @default.
- W1539960807 cites W2066559116 @default.
- W1539960807 cites W2066926304 @default.
- W1539960807 cites W2071777829 @default.
- W1539960807 cites W2085381168 @default.
- W1539960807 cites W2085681533 @default.
- W1539960807 cites W2086287178 @default.
- W1539960807 cites W2087702258 @default.
- W1539960807 cites W2088846316 @default.
- W1539960807 cites W2089597181 @default.
- W1539960807 cites W2090541352 @default.
- W1539960807 cites W2091615898 @default.
- W1539960807 cites W2094777850 @default.
- W1539960807 cites W2095751352 @default.
- W1539960807 cites W2100452328 @default.
- W1539960807 cites W2100729071 @default.
- W1539960807 cites W2106140689 @default.
- W1539960807 cites W2109014958 @default.
- W1539960807 cites W2109154308 @default.
- W1539960807 cites W2109254532 @default.
- W1539960807 cites W2110854394 @default.
- W1539960807 cites W2113183595 @default.
- W1539960807 cites W2117029147 @default.
- W1539960807 cites W2118733371 @default.
- W1539960807 cites W2124035137 @default.
- W1539960807 cites W2127656622 @default.
- W1539960807 cites W2134891904 @default.
- W1539960807 cites W2137588110 @default.
- W1539960807 cites W2149963584 @default.
- W1539960807 cites W2150981663 @default.
- W1539960807 cites W2154320984 @default.
- W1539960807 cites W2156871793 @default.
- W1539960807 cites W2157542919 @default.
- W1539960807 cites W2162109316 @default.
- W1539960807 cites W2162210570 @default.
- W1539960807 cites W2164608227 @default.
- W1539960807 cites W2166083626 @default.
- W1539960807 cites W2330268139 @default.
- W1539960807 doi "https://doi.org/10.1016/j.bpj.2015.06.046" @default.
- W1539960807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4572577" @default.
- W1539960807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26244742" @default.
- W1539960807 hasPublicationYear "2015" @default.
- W1539960807 type Work @default.
- W1539960807 sameAs 1539960807 @default.
- W1539960807 citedByCount "6" @default.
- W1539960807 countsByYear W15399608072016 @default.
- W1539960807 countsByYear W15399608072017 @default.
- W1539960807 countsByYear W15399608072018 @default.