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- W1539969118 abstract "Oligosaccharides of different sizes were prepared by acid hydrolysis of group A streptococcal carbohydrate. Separation of the oligosaccharides was performed by dialysis and chromatography on G-25 Sephadex. The activity of β-N-acetylglucosaminidase enzymes derived from the soil bacillus and from macrophage cells was assessed on the various haptens. The soil bacillus enzyme was equally active on the various sized haptens. However, the activity of the macrophage enzyme was strictly related to the size of the oligosaccharide, with hydrolytic activity increasing with decreasing size of the substrate. The capacity of the oligosaccharide fragments to inhibit the reaction between the group A polysaccharide and its antibody was studied using a radioimmune precipitation technique. The capacity of the haptens to inhibit antibody was directly related to the molecular weight of the oligosaccharides. Both the soil bacillus and macrophage β-N-acetylglucosaminidases were effective in eliminating most of the antibody inhibitory activity of the haptens, although this was achieved at lower concentrations of the soil bacillus enzyme. The amount of macrophage enzyme required to achieve a similar decrease in the antibody inhibitory activity of the haptens increased proportionately to the size of the haptens." @default.
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- W1539969118 date "1970-08-01" @default.
- W1539969118 modified "2023-09-23" @default.
- W1539969118 title "Streptococcal group a polysaccharide haptens: susceptibility to degradation by beta-N-acetylglucosaminidases and antibody-combining capacity of haptens." @default.
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