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• W1540007527 abstract "Abstract Ionizing radiation therapy is a crucial treatment for cancer, but can damage surrounding normal tissues. Damage to articular cartilage leading to arthropathy can occur at irradiated sites. It is unclear whether this response is due to damaging surrounding skeletal structures or direct effects on cartilage. In this study, we showed that irradiation with 2 Gy of X‐rays causes a significant reduction in the stiffness of porcine explants 1 week post‐irradiation. By using both microindentation and indentation‐type atomic force microscopy, ionizing radiation reduces stiffness in both the superficial zone, and throughout the entire thickness of the tissue. Young's modulus values were 75% and 60% lower in 2 Gy irradiated samples when compared with controls using microindentation and nanoindentation, respectively. Glycosaminoglycans (GAGs) released into the culture media of irradiated samples was nearly 100% greater at 24 h after exposure. While collagen content in the tissue is similar between groups, GAG content is 55% lower in irradiated explants compared with controls 7 days after exposure. Therefore, the irradiated explants are unable to recover from the initial loss of GAGs by 1 week. This acute loss of GAGs is a likely contributor to the reduction in modulus seen after exposure to ionizing radiation. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1780–1785, 2013" @default.
• W1540007527 created "2016-06-24" @default.
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• W1540007527 date "2013-08-01" @default.
• W1540007527 modified "2023-10-04" @default.
• W1540007527 title "Effects of low dose X-ray irradiation on porcine articular cartilage explants" @default.
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• W1540007527 doi "https://doi.org/10.1002/jor.22406" @default.
• W1540007527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3792489" @default.
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