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- W1540182210 abstract "Aberrations in estrogen signaling increase breast cancer risk. Molecular mechanisms that impact breast cancer initiation, promotion, and progression can be investigated using genetically engineered mouse models. Increasing estrogen receptor alpha (ERα) expression levels twofold is sufficient to initiate and promote breast cancer progression. Initiation and promotion can be increased by p53 haploinsufficiency and by coexpressing the nuclear coactivators amplified in breast cancer 1 (AIB1) or the splice variant AIB1Δ3. Progression to invasive cancer is found with coexpression of these nuclear coactivators as well as following a single dose of 7,12‐dimethylbenz(a)anthracene. Loss of signal transducer and activator of transcription 5a reduces the prevalence of initiation and promotion but does not protect from invasive cancer development. Cyclin D1 loss completely interrupts mammary epithelial proliferation and survival when ERα is overexpressed. Loss of breast cancer gene 1 increases estrogen signaling and cooperates with ERα overexpression in initiation, promotion, and progression of mammary cancer." @default.
- W1540182210 created "2016-06-24" @default.
- W1540182210 creator A5023196554 @default.
- W1540182210 creator A5023506665 @default.
- W1540182210 creator A5053625755 @default.
- W1540182210 creator A5059102143 @default.
- W1540182210 creator A5089837987 @default.
- W1540182210 date "2011-07-01" @default.
- W1540182210 modified "2023-10-06" @default.
- W1540182210 title "Assessing estrogen signaling aberrations in breast cancer risk using genetically engineered mouse models" @default.
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