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• W1540207837 abstract "Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in vivo model. By changing focus from secretion of fluid to secretion of protein and of acinar amylase a secretory role was found not only for gastrin and cholecystokinin but also for the non-traditional gastro-intestinal hormone melatonin. Neither intravenous infusion of the hormone-analogues pentagastrin and desulfated cholecystokinin-8 nor of melatonin evoked any overt fluid secretion from the duct-cannulated gland. However, a subsequent intravenous wash-out injection of the secretagogue methacholine revealed protein/amylase secretion in response to the infusion of the hormone/hormone-analogues. The hormone/hormone-analogues exerted their effect directly on the gland cells: it persisted in the presence of ?- and ?-adrenoceptor antagonists, after disconnecting the gland from its peripheral ganglia and after evisceration. The gland protein synthesis increased to pentagastrin. Cholecystokinin(CCK) -A and CCK-B receptor types as well as the melatonin receptors, MT1 and MT2, were expressed in the gland. By the use of hormone-receptor antagonists, protein secretion was shown to involve mainly the CCK-A receptors and the MT2 receptors, whereas both types of cholecystokinin receptors were involved in the protein synthesis. The secretion of protein/amylase and the synthesis of protein to the hormone/ hormone-analogues were partially dependent on nitric oxide generated by the activity of neuronal type NO-synthase, probably of parenchymal origin. Cholecystokinin may occur as a transmitter in the peripheral nervous system and, hypothetical, cholecystokinin might belong to the group of parasympathetic non-adrenergic, non-cholinergic transmitters that upon stimulation of the parasympathetic auriculo-temporal nerve evokes secretion of fluid and, in particular, secretion of protein/amylase. However, the stimulation of the parasympathetic innervation, in the presence of cholecystokinin receptor antagonists, gave no support for a transmitter role for cholecystokinin in the gland. Lipopolysaccharide injected intraductally towards the parotid gland induced inflammation, as shown by neutrophil infiltration and increased myeloperoxidase activity in the gland, and mobilization of ?-defensins, being a part of the oral defense mechanism. Melatonin and cholecystokinin (sulfated CCK-8) administered intraperitoneally exerted anti-inflammatory actions in the inflamed gland as judged by reduced levels of the elevated activity of myeloperoxidase. The effect of melatonin was non-receptor mediated, while that of sulfated CCK-8 was partially dependent on CCK-A receptors. The inflammatory response involved NO generated from inducible NO-synthase and neuronal type of NO-synthase as shown by selective NO-synthase inhibitors, the neuronal type being most likely of parenchymal origin, since it was activated also in the chronically denervated gland. In conclusion, the secretory activity of salivary glands seems not only to be regulated by a cephalic phase of nervous activity but also by a gastric phase and an intestinal phase of endocrine activity. Circulating melatonin and cholecystokinin/gastrin may not only influence the secretory activity but may also protect the salivary glands from inflammation. The present findings have implications for salivary gland dysfunction/dry mouth and its treatment." @default.
• W1540207837 created "2016-06-24" @default.
• W1540207837 creator A5036380278 @default.
• W1540207837 date "2009-09-17" @default.
• W1540207837 modified "2023-09-27" @default.
• W1540207837 title "Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands" @default.
• W1540207837 cites W102667020 @default.
• W1540207837 cites W105688798 @default.
• W1540207837 cites W1486802419 @default.
• W1540207837 cites W1489660283 @default.
• W1540207837 cites W1508832851 @default.
• W1540207837 cites W1549505983 @default.
• W1540207837 cites W1557366298 @default.
• W1540207837 cites W1560955538 @default.
• W1540207837 cites W1564326393 @default.
• W1540207837 cites W1582305715 @default.
• W1540207837 cites W1654889763 @default.
• W1540207837 cites W1667551924 @default.
• W1540207837 cites W1712951338 @default.
• W1540207837 cites W1775749144 @default.
• W1540207837 cites W1786059057 @default.
• W1540207837 cites W1791996532 @default.
• W1540207837 cites W180781382 @default.
• W1540207837 cites W1825406417 @default.
• W1540207837 cites W1842060488 @default.
• W1540207837 cites W1852348769 @default.
• W1540207837 cites W186381728 @default.
• W1540207837 cites W1879044889 @default.
• W1540207837 cites W1893813561 @default.
• W1540207837 cites W1913186869 @default.
• W1540207837 cites W1929009802 @default.
• W1540207837 cites W1964901554 @default.
• W1540207837 cites W1971245779 @default.
• W1540207837 cites W1975666527 @default.
• W1540207837 cites W1978925127 @default.
• W1540207837 cites W1980090948 @default.
• W1540207837 cites W1984007105 @default.
• W1540207837 cites W1984289260 @default.
• W1540207837 cites W1984822388 @default.
• W1540207837 cites W1987993281 @default.
• W1540207837 cites W1989272070 @default.
• W1540207837 cites W1989418616 @default.
• W1540207837 cites W1991060266 @default.
• W1540207837 cites W1991670388 @default.
• W1540207837 cites W1997522568 @default.
• W1540207837 cites W2000228644 @default.
• W1540207837 cites W2002211351 @default.
• W1540207837 cites W2004608741 @default.
• W1540207837 cites W2006548803 @default.
• W1540207837 cites W2006936746 @default.
• W1540207837 cites W2009775667 @default.
• W1540207837 cites W2010293687 @default.
• W1540207837 cites W2015840178 @default.
• W1540207837 cites W2016234249 @default.
• W1540207837 cites W2019008147 @default.
• W1540207837 cites W2020041852 @default.
• W1540207837 cites W2020358486 @default.
• W1540207837 cites W2022018558 @default.
• W1540207837 cites W2022432945 @default.
• W1540207837 cites W2026996407 @default.
• W1540207837 cites W2027293512 @default.
• W1540207837 cites W2028142213 @default.
• W1540207837 cites W2030629956 @default.
• W1540207837 cites W2030975744 @default.
• W1540207837 cites W2032508216 @default.
• W1540207837 cites W2033794828 @default.
• W1540207837 cites W2037857399 @default.
• W1540207837 cites W2040200544 @default.
• W1540207837 cites W2042462899 @default.
• W1540207837 cites W2044141517 @default.
• W1540207837 cites W2045802983 @default.
• W1540207837 cites W2046397683 @default.
• W1540207837 cites W2046971860 @default.
• W1540207837 cites W2048357165 @default.
• W1540207837 cites W2052793355 @default.
• W1540207837 cites W2055724104 @default.
• W1540207837 cites W2058423921 @default.
• W1540207837 cites W2060406163 @default.
• W1540207837 cites W2060584083 @default.
• W1540207837 cites W2060621214 @default.
• W1540207837 cites W2060670294 @default.
• W1540207837 cites W2063757278 @default.
• W1540207837 cites W2063986585 @default.
• W1540207837 cites W2065365325 @default.
• W1540207837 cites W2067166404 @default.
• W1540207837 cites W2067887019 @default.
• W1540207837 cites W2072687189 @default.
• W1540207837 cites W2074724190 @default.
• W1540207837 cites W2077936233 @default.
• W1540207837 cites W2080153629 @default.
• W1540207837 cites W2081004928 @default.
• W1540207837 cites W2081324926 @default.
• W1540207837 cites W2082152104 @default.
• W1540207837 cites W2087332824 @default.
• W1540207837 cites W2087733046 @default.
• W1540207837 cites W2088434862 @default.
• W1540207837 cites W2090102582 @default.
• W1540207837 cites W2098125899 @default.
• W1540207837 cites W2098217572 @default.
• W1540207837 cites W2098561534 @default.

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