Matches in SemOpenAlex for { <https://semopenalex.org/work/W1540228912> ?p ?o ?g. }
- W1540228912 endingPage "65" @default.
- W1540228912 startingPage "449" @default.
- W1540228912 abstract "Stochastic damage to cellular macromolecules and organelles is thought to be a driving force behind aging and associated degenerative changes. However, stress response pathways activated by this damage may also contribute to aging. The IKK/NF-κB signaling pathway has been proposed to be one of the key mediators of aging. It is activated by genotoxic, oxidative, and inflammatory stresses and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell cycle progression, cell senescence, and inflammation. Transcriptional activity of NF-κB is increased in a variety of tissues with aging and is associated with numerous age-related degenerative diseases including Alzheimer's, diabetes and osteoporosis. In mouse models, inhibition of NF-κB leads to delayed onset of age-related symptoms and pathologies. In addition, NF-κB activation is linked with many of the known lifespan regulators including insulin/IGF-1, FOXO, SIRT, mTOR, and DNA damage. Thus NF-κB represents a possible therapeutic target for extending mammalian healthspan." @default.
- W1540228912 created "2016-06-24" @default.
- W1540228912 creator A5040467127 @default.
- W1540228912 creator A5043039694 @default.
- W1540228912 creator A5075456560 @default.
- W1540228912 creator A5076276521 @default.
- W1540228912 date "2011-12-01" @default.
- W1540228912 modified "2023-10-17" @default.
- W1540228912 title "NF-κB in Aging and Disease." @default.
- W1540228912 cites W1483141002 @default.
- W1540228912 cites W1491280754 @default.
- W1540228912 cites W1515578871 @default.
- W1540228912 cites W1519633296 @default.
- W1540228912 cites W1522354953 @default.
- W1540228912 cites W1534360145 @default.
- W1540228912 cites W1585782290 @default.
- W1540228912 cites W1764140709 @default.
- W1540228912 cites W1775947750 @default.
- W1540228912 cites W1822935226 @default.
- W1540228912 cites W1881072801 @default.
- W1540228912 cites W1933184123 @default.
- W1540228912 cites W1935070596 @default.
- W1540228912 cites W1951075546 @default.
- W1540228912 cites W1965414585 @default.
- W1540228912 cites W1967378743 @default.
- W1540228912 cites W1967937835 @default.
- W1540228912 cites W1969999276 @default.
- W1540228912 cites W1970479761 @default.
- W1540228912 cites W1970606114 @default.
- W1540228912 cites W1972256954 @default.
- W1540228912 cites W1973856122 @default.
- W1540228912 cites W1974924674 @default.
- W1540228912 cites W1975527161 @default.
- W1540228912 cites W1977348907 @default.
- W1540228912 cites W1979437866 @default.
- W1540228912 cites W1981148605 @default.
- W1540228912 cites W1985236996 @default.
- W1540228912 cites W1985534077 @default.
- W1540228912 cites W1988226967 @default.
- W1540228912 cites W1991221096 @default.
- W1540228912 cites W1993753481 @default.
- W1540228912 cites W1994394172 @default.
- W1540228912 cites W1997326200 @default.
- W1540228912 cites W1999048147 @default.
- W1540228912 cites W1999177172 @default.
- W1540228912 cites W1999692789 @default.
- W1540228912 cites W1999703499 @default.
- W1540228912 cites W2004984537 @default.
- W1540228912 cites W2017695738 @default.
- W1540228912 cites W2018554367 @default.
- W1540228912 cites W2022202246 @default.
- W1540228912 cites W2023949591 @default.
- W1540228912 cites W2024969918 @default.
- W1540228912 cites W2027042806 @default.
- W1540228912 cites W2027109644 @default.
- W1540228912 cites W2027776687 @default.
- W1540228912 cites W2028525107 @default.
- W1540228912 cites W2029820788 @default.
- W1540228912 cites W2030782357 @default.
- W1540228912 cites W2031637294 @default.
- W1540228912 cites W2032766057 @default.
- W1540228912 cites W2035695710 @default.
- W1540228912 cites W2036285327 @default.
- W1540228912 cites W2038378083 @default.
- W1540228912 cites W2038996595 @default.
- W1540228912 cites W2045201133 @default.
- W1540228912 cites W2045532799 @default.
- W1540228912 cites W2048516545 @default.
- W1540228912 cites W2049197565 @default.
- W1540228912 cites W2052396430 @default.
- W1540228912 cites W2052899770 @default.
- W1540228912 cites W2054059225 @default.
- W1540228912 cites W2055539528 @default.
- W1540228912 cites W2058120050 @default.
- W1540228912 cites W2058484936 @default.
- W1540228912 cites W2058531263 @default.
- W1540228912 cites W2058647415 @default.
- W1540228912 cites W2059724105 @default.
- W1540228912 cites W2060482414 @default.
- W1540228912 cites W2061785327 @default.
- W1540228912 cites W2062368346 @default.
- W1540228912 cites W2062711706 @default.
- W1540228912 cites W2063084036 @default.
- W1540228912 cites W2064711537 @default.
- W1540228912 cites W2066762007 @default.
- W1540228912 cites W2071695496 @default.
- W1540228912 cites W2073701988 @default.
- W1540228912 cites W2073788442 @default.
- W1540228912 cites W2074177924 @default.
- W1540228912 cites W2074346842 @default.
- W1540228912 cites W2074916731 @default.
- W1540228912 cites W2075900101 @default.
- W1540228912 cites W2075939588 @default.
- W1540228912 cites W2079536916 @default.
- W1540228912 cites W2080929675 @default.
- W1540228912 cites W2082067798 @default.
- W1540228912 cites W2083022068 @default.
- W1540228912 cites W2085073238 @default.