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- W1540280069 abstract "4547 Purpose:Patients with non-small cell lung cancer (NSCLC) harboring activating somatic mutations of epidermal growth factor receptor (EGFR) are highly sensitive to the EGFR- tyrosine kinase inhibitor: gefitinib. We examined the detection of the EGFR gene mutation prospectively using a variety of daily specimens of NSCLC patients. The response to the gefitinib treatment was also evaluated. Patients and Methods: We prospectively evaluated 104 daily obtained specimens of 91 NSCLC Japnanese patients for EGFR mutations in exon 18-23. Isolated DNA were obtained from surgical direct or paraffin-embedded specimens, biopsied or cytology samples by fine needle biopsy or by transbronchoscopic biopsy, pleural effusions, and pericardial effusion. Results: Thirty-two mutations including deletions in exon 19 in 23 patients and L858R in 9 patients were detected. The frequency of the mutation were 47.2% (paraffin-embedded surgical lung specimens), 42.9% (fresh surgical or biopsied specimens), 38.1% (transbronchoscopic biopsied samples), 30.8% (transbronchoscopic cytology samples), 42.9% (biopsied samples from metastatic lesion) and 30.8% (pleural or pericardial effusion samples). Response rate of gefitinib treatment in patients with EGFR mutation was 65.0% (13 of 20 patients) compared to 37.5% (3 of 8 patients) in patients without mutation. Conclusion: Although lower than from surgical specimens, we could detect the EGFR mutations from daily available specimens. The detection of the EGFR gene mutations from diagnostic tumor specimens may make it possible to induce the first line gefitinib treatment." @default.
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- W1540280069 date "2006-04-15" @default.
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- W1540280069 title "Detection of EGFR gene mutations from daily obtained specimens in NSCLC patients" @default.
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