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- W1540286959 abstract "In this study, the in vivo binding of 14C-labelled 2-mercaptobenzothiazole (MBT) to DNA was investigated. Male and female Fischer 344 rats were gavaged with 375 mg MBT/kg body weight and killed 8 hours later. DNA was extracted from the liver, adrenal glands, pituitary gland, pancreas, and bone marrow and the amount of radioactivity associated with the DNA was determined. Results from this study indicate that MBT does not significantly bind to DNA from any of the tissues examined. CBI values for liver for the 3 methods of purification were ∼1–3 which are on the low end of the covalent binding index. The CBI values for the other tissues were always <1. Other chemicals with similar CBI values include estrone and diethylstilbesterol. Strong hepatocarcinogens such as dimethylnitrosamine and aflatoxin have CBI values ranging from 6000 to greater than 20000." @default.
- W1540286959 created "2016-06-24" @default.
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- W1540286959 date "1987-03-01" @default.
- W1540286959 modified "2023-10-18" @default.
- W1540286959 title "Deficiencies in the covalent binding idnex (CBI) for expressing in vivo binding to DNA with respect to predicting chemical carcinogenicity" @default.
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- W1540286959 doi "https://doi.org/10.1016/0165-7992(87)90024-8" @default.
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