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- W1540292823 abstract "Microglia is increasingly recognized to play a crucial role in the pathogenesis of psychiatric diseases. In particular, microglia may be the cellular link between inflammation and behavioral alterations: by releasing a number of soluble factors, among which pro-inflammatory cytokines, that can regulate synaptic activity, thereby leading to perturbation of behavior. In multiple sclerosis (MS), the most common neuroinflammatory disorder affecting young adults, microglia activation and dysfunction may account for mood symptoms, like depression and anxiety, that are often diagnosed in patients even in the absence of motor disability. Behavioral studies in experimental autoimmune encephalomyelitis (EAE), the animal model of MS, have shown that emotional changes occur early in the disease and in correlation to inflammatory mediator and neurotransmitter level alterations. However, such studies lack a full and comprehensive analysis of the role played by microglia in EAE-behavioral syndrome. We review the experimental studies addressing behavioral symptoms in EAE, and propose the study of neuron-glia interaction as a powerful but still poorly explored tool to investigate the burden of microglia in mood alterations associated to MS." @default.
- W1540292823 created "2016-06-24" @default.
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- W1540292823 date "2015-06-25" @default.
- W1540292823 modified "2023-10-16" @default.
- W1540292823 title "Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis" @default.
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- W1540292823 cites W121772056 @default.
- W1540292823 cites W1670760818 @default.
- W1540292823 cites W1967025818 @default.
- W1540292823 cites W1968248096 @default.
- W1540292823 cites W1978292506 @default.
- W1540292823 cites W1979312949 @default.
- W1540292823 cites W1982807477 @default.
- W1540292823 cites W1983342099 @default.
- W1540292823 cites W1990487655 @default.
- W1540292823 cites W1993466811 @default.
- W1540292823 cites W1994216586 @default.
- W1540292823 cites W1996454121 @default.
- W1540292823 cites W2004265420 @default.
- W1540292823 cites W2005035120 @default.
- W1540292823 cites W2006468214 @default.
- W1540292823 cites W2013254203 @default.
- W1540292823 cites W2013413557 @default.
- W1540292823 cites W2014026586 @default.
- W1540292823 cites W2014797499 @default.
- W1540292823 cites W2015407094 @default.
- W1540292823 cites W2016867017 @default.
- W1540292823 cites W2020407498 @default.
- W1540292823 cites W2028045647 @default.
- W1540292823 cites W2028131345 @default.
- W1540292823 cites W2033617297 @default.
- W1540292823 cites W2036091553 @default.
- W1540292823 cites W2036399741 @default.
- W1540292823 cites W2040581913 @default.
- W1540292823 cites W2044547913 @default.
- W1540292823 cites W2047563225 @default.
- W1540292823 cites W2047570180 @default.
- W1540292823 cites W2048938277 @default.
- W1540292823 cites W2052424568 @default.
- W1540292823 cites W2055462534 @default.
- W1540292823 cites W2055839901 @default.
- W1540292823 cites W2057450652 @default.
- W1540292823 cites W2061178742 @default.
- W1540292823 cites W2061182026 @default.
- W1540292823 cites W2062741020 @default.
- W1540292823 cites W2067267561 @default.
- W1540292823 cites W2068641884 @default.
- W1540292823 cites W2070899132 @default.
- W1540292823 cites W2077735428 @default.
- W1540292823 cites W2077857103 @default.
- W1540292823 cites W2080157375 @default.
- W1540292823 cites W2082377187 @default.
- W1540292823 cites W2082428529 @default.
- W1540292823 cites W2085202176 @default.
- W1540292823 cites W2087146795 @default.
- W1540292823 cites W2089733095 @default.
- W1540292823 cites W2089735092 @default.
- W1540292823 cites W2100486394 @default.
- W1540292823 cites W2101191370 @default.
- W1540292823 cites W2101815841 @default.
- W1540292823 cites W2107480122 @default.
- W1540292823 cites W2112843710 @default.
- W1540292823 cites W2115402978 @default.
- W1540292823 cites W2116416756 @default.
- W1540292823 cites W2116794070 @default.
- W1540292823 cites W2120228158 @default.
- W1540292823 cites W2120306544 @default.
- W1540292823 cites W2122384242 @default.
- W1540292823 cites W2126795224 @default.
- W1540292823 cites W2128215483 @default.
- W1540292823 cites W2135641533 @default.
- W1540292823 cites W2137247202 @default.
- W1540292823 cites W2142005071 @default.
- W1540292823 cites W2142103247 @default.
- W1540292823 cites W2148602027 @default.
- W1540292823 cites W2153409966 @default.
- W1540292823 cites W2153537282 @default.
- W1540292823 cites W2156443184 @default.
- W1540292823 cites W2157400052 @default.
- W1540292823 cites W2162460585 @default.
- W1540292823 cites W2170899083 @default.
- W1540292823 cites W2171549018 @default.
- W1540292823 cites W2416597160 @default.
- W1540292823 cites W36973339 @default.
- W1540292823 cites W4211254511 @default.
- W1540292823 doi "https://doi.org/10.3389/fncel.2015.00243" @default.
- W1540292823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4479791" @default.
- W1540292823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26161070" @default.
- W1540292823 hasPublicationYear "2015" @default.
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