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- W1540374315 abstract "Abstract Cancer is a disease in which genetic alterations, most frequently chromosomal rearrangements, are acquired in somatic cells resulting in loss of critical cellular checks and balances. This leads to cellular dysregulation, proliferation, and ultimately, malignant transformation. Cancer cytogenetics is the subdiscipline of genetics in which the chromosomal abnormalities present in cancers are identified and investigated. This includes correlation of the cytogenetic abnormalities with clinical diagnosis, prognosis and response to therapy, and may extend to identification of the genes disrupted and/or dysregulated as a result of the chromosomal aberrations. The history of cancer cytogenetics, a description the cytogenetic methodology that has developed and evolved over the past half‐century, clinical applications of cancer cytogenetics, and mechanisms by which cytogenetic abnormalities arise in cancer cells are described in this contribution to the literature." @default.
- W1540374315 created "2016-06-24" @default.
- W1540374315 creator A5011138786 @default.
- W1540374315 date "2005-04-15" @default.
- W1540374315 modified "2023-10-18" @default.
- W1540374315 title "Acquired chromosome abnormalities: the cytogenetics of cancer" @default.
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- W1540374315 doi "https://doi.org/10.1002/047001153x.g102204" @default.
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