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• W1540376590 abstract "Matrix metalloproteinase-8 (MMP8) has been shown to influence various cellular functions. As monocytes and macrophages (Mϕ) express MMP8, we investigated if MMP8 played a role in macrophage differentiation and polarization. MMP8 expression was significantly increased during monocyte differentiation into Mϕ. Monocyte-derived Mϕ from MMP8-deficient mice expressed higher levels of M1-Mϕ markers but lower levels of M2-Mϕ markers than monocyte-derived Mϕ from wild-type mice. Although Mϕ from either MMP8-deficient or wild-type mice were inducible by interferon-γ into M1-Mϕ, only wild-type Mϕ but not MMP8-deficient Mϕ could be induced into M2-Mϕ by interleukin-4. However, MMP8-deficient Mϕ exposed to conditioned culture media of wild-type Mϕ developed a M2-Mϕ phenotype. Compared with conditioned culture media of wild-type Mϕ, conditioned culture media of MMP8-deficient Mϕ contained a lower concentration of active transforming growth factor-β (TGF-β), an M2-Mϕ inducer. Moreover, evidence also showed that the degradation of the TGF-β sequester, fibromodulin, was modulated by MMP8. The data indicate a previously unknown role of MMP8 in M2-Mϕ polarization by cleaving fibromodulin and therefore increasing the bioavailability of the M2-Mϕ inducer TGF-β. Matrix metalloproteinase-8 (MMP8) has been shown to influence various cellular functions. As monocytes and macrophages (Mϕ) express MMP8, we investigated if MMP8 played a role in macrophage differentiation and polarization. MMP8 expression was significantly increased during monocyte differentiation into Mϕ. Monocyte-derived Mϕ from MMP8-deficient mice expressed higher levels of M1-Mϕ markers but lower levels of M2-Mϕ markers than monocyte-derived Mϕ from wild-type mice. Although Mϕ from either MMP8-deficient or wild-type mice were inducible by interferon-γ into M1-Mϕ, only wild-type Mϕ but not MMP8-deficient Mϕ could be induced into M2-Mϕ by interleukin-4. However, MMP8-deficient Mϕ exposed to conditioned culture media of wild-type Mϕ developed a M2-Mϕ phenotype. Compared with conditioned culture media of wild-type Mϕ, conditioned culture media of MMP8-deficient Mϕ contained a lower concentration of active transforming growth factor-β (TGF-β), an M2-Mϕ inducer. Moreover, evidence also showed that the degradation of the TGF-β sequester, fibromodulin, was modulated by MMP8. The data indicate a previously unknown role of MMP8 in M2-Mϕ polarization by cleaving fibromodulin and therefore increasing the bioavailability of the M2-Mϕ inducer TGF-β." @default.
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• W1540376590 date "2015-07-01" @default.
• W1540376590 modified "2023-10-01" @default.
• W1540376590 title "A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization" @default.
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• W1540376590 doi "https://doi.org/10.1074/jbc.m114.634022" @default.
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