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- W1540441570 abstract "It has been more than 20 years since it first became clear that the proliferation of nontransformed cells depended upon signals from both mitogenic growth factors and adhesion to the extracellular matrix. During this time, many studies have examined the role of mitogens in growth control, and the molecular effects of mitogens on cell cycle progression are now relatively well understood. More recently, the cell cycle concepts that have been derived from the study of growth factors have been applied to understanding how cell anchorage controls proliferation. Indeed, it now seems that the G1 phase cyclin-dependent kinase system that has been so closely linked to growth factor action is actually regulated coordinately with signals provided by growth factors, cell adhesion to extracellular matrix, and the adhesion-dependent organization of the cytoskeleton. This chapter reviews the studies that have contributed to our understanding of the extracellular matrix as a source of growth regulatory information." @default.
- W1540441570 created "2016-06-24" @default.
- W1540441570 creator A5050311944 @default.
- W1540441570 creator A5071772212 @default.
- W1540441570 creator A5078338308 @default.
- W1540441570 creator A5089942489 @default.
- W1540441570 date "1997-01-01" @default.
- W1540441570 modified "2023-09-27" @default.
- W1540441570 title "Role of the Extracellular Matrix and Cytoskeleton in the Regulation of Cyclins, Cyclindependent Kinase Inhibitors, and Anchorage-Dependent Growth" @default.
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