Matches in SemOpenAlex for { <https://semopenalex.org/work/W1540532087> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1540532087 endingPage "12279" @default.
- W1540532087 startingPage "12274" @default.
- W1540532087 abstract "The six accessory proteins of the bacteriophage T4 specified by replication genes 32, 41, 44, 45, 61, and 62 were studied for their ability to enhance the accuracy with which phage T4 DNA polymerase (product of gene 43) replicates synthetic homopolymer duplexes in vitro. Two of these proteins, gene 32-protein (helix-destabilizing protein) and gene 45-protein, inhibited the selection of incorrect, but not correct, precursors, at the growing strand end. Gene 32-protein is shown to enhance replication fidelity by interacting with the DNA, whereas gene 45-protein exerts its fidelity-enhancing effect by interacting with the DNA polymerase. This is the first example to our knowledge of a DNA polymerase's accuracy being altered through interaction with another protein. Possible mechanisms by which gene 32- and gene 45-protein act to enhance replication fidelity are discussed." @default.
- W1540532087 created "2016-06-24" @default.
- W1540532087 creator A5083311745 @default.
- W1540532087 creator A5083870875 @default.
- W1540532087 date "1983-10-01" @default.
- W1540532087 modified "2023-09-30" @default.
- W1540532087 title "Products of bacteriophage T4 genes 32 and 45 improve the accuracy of DNA replication in vitro." @default.
- W1540532087 cites W1495495884 @default.
- W1540532087 cites W1495890091 @default.
- W1540532087 cites W1501149994 @default.
- W1540532087 cites W1501990563 @default.
- W1540532087 cites W1507551858 @default.
- W1540532087 cites W1528818827 @default.
- W1540532087 cites W1533449639 @default.
- W1540532087 cites W1533992712 @default.
- W1540532087 cites W1544482700 @default.
- W1540532087 cites W1608195340 @default.
- W1540532087 cites W1967460034 @default.
- W1540532087 cites W2008488679 @default.
- W1540532087 cites W2042755167 @default.
- W1540532087 cites W2049947190 @default.
- W1540532087 cites W2050445949 @default.
- W1540532087 cites W2052831849 @default.
- W1540532087 cites W2057979557 @default.
- W1540532087 cites W2063198775 @default.
- W1540532087 cites W2087859334 @default.
- W1540532087 cites W2164924691 @default.
- W1540532087 cites W2330047747 @default.
- W1540532087 cites W2330257307 @default.
- W1540532087 doi "https://doi.org/10.1016/s0021-9258(17)44170-6" @default.
- W1540532087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6355084" @default.
- W1540532087 hasPublicationYear "1983" @default.
- W1540532087 type Work @default.
- W1540532087 sameAs 1540532087 @default.
- W1540532087 citedByCount "35" @default.
- W1540532087 countsByYear W15405320872012 @default.
- W1540532087 crossrefType "journal-article" @default.
- W1540532087 hasAuthorship W1540532087A5083311745 @default.
- W1540532087 hasAuthorship W1540532087A5083870875 @default.
- W1540532087 hasBestOaLocation W15405320871 @default.
- W1540532087 hasConcept C104317684 @default.
- W1540532087 hasConcept C12590798 @default.
- W1540532087 hasConcept C159047783 @default.
- W1540532087 hasConcept C202751555 @default.
- W1540532087 hasConcept C2776441376 @default.
- W1540532087 hasConcept C54355233 @default.
- W1540532087 hasConcept C547475151 @default.
- W1540532087 hasConcept C552990157 @default.
- W1540532087 hasConcept C70721500 @default.
- W1540532087 hasConcept C73573662 @default.
- W1540532087 hasConcept C86803240 @default.
- W1540532087 hasConceptScore W1540532087C104317684 @default.
- W1540532087 hasConceptScore W1540532087C12590798 @default.
- W1540532087 hasConceptScore W1540532087C159047783 @default.
- W1540532087 hasConceptScore W1540532087C202751555 @default.
- W1540532087 hasConceptScore W1540532087C2776441376 @default.
- W1540532087 hasConceptScore W1540532087C54355233 @default.
- W1540532087 hasConceptScore W1540532087C547475151 @default.
- W1540532087 hasConceptScore W1540532087C552990157 @default.
- W1540532087 hasConceptScore W1540532087C70721500 @default.
- W1540532087 hasConceptScore W1540532087C73573662 @default.
- W1540532087 hasConceptScore W1540532087C86803240 @default.
- W1540532087 hasIssue "20" @default.
- W1540532087 hasLocation W15405320871 @default.
- W1540532087 hasOpenAccess W1540532087 @default.
- W1540532087 hasPrimaryLocation W15405320871 @default.
- W1540532087 hasRelatedWork W1982771726 @default.
- W1540532087 hasRelatedWork W2005864317 @default.
- W1540532087 hasRelatedWork W2034984548 @default.
- W1540532087 hasRelatedWork W2058462727 @default.
- W1540532087 hasRelatedWork W2062722774 @default.
- W1540532087 hasRelatedWork W2084555268 @default.
- W1540532087 hasRelatedWork W2088301344 @default.
- W1540532087 hasRelatedWork W2143969389 @default.
- W1540532087 hasRelatedWork W2163275718 @default.
- W1540532087 hasRelatedWork W4238567963 @default.
- W1540532087 hasVolume "258" @default.
- W1540532087 isParatext "false" @default.
- W1540532087 isRetracted "false" @default.
- W1540532087 magId "1540532087" @default.
- W1540532087 workType "article" @default.