FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1540564953> ?p ?o ?g. }

• W1540564953 abstract "Gynecologic malignancies count for about 80,000 of all new cancer diagnoses in women in the United States (Jemal et al., 2010). In the US almost 20,000 patients a year are diagnosed with epithelial ovarian cancer, 11,000 with cervical cancer and 42,000 with endometrial cancer (Jemal et al., 2010). A relevant part of these tumor situations are found in an earlystage disease setting, for instance most of all newly diagnosed endometrial cancers. But frequently there is no possibility for an early-stage diagnosis and the tumor is already advanced when primarily detected, like in the majority of all cases with epithelial ovarian cancer (EOC). Though tumor biology and standard treatment concepts are different for all three entities, there is a common need for new therapeutic approaches to improve the patients’ outcome. Many preclinical studies have suggested that antiangiogenic strategies are beneficial against these cancers (Delli Carpini, 2010). One reason may be the fact that these tumors are able to form large single tumor nodulations during intraabdominal spread or local progression with hypoxic cores triggering tumor-associated neo-angiogenesis (Bryant et al., 2010). Furthermore, the frequently seen phenomenon of peritoneal carcinosis, closely related to gynecologic malignancies, induces angiogenesis to preserve nutritive supply to all metastatic tumor nodes (Fagotti et al., 2010, Figure 1). Since Folkman first proposed the strategy of targeting the tumor vasculature as a novel therapeutic strategy, considerable progress has been made to understand the underlying mechanisms of angiogenesis (Folkman, 1971). The control of angiogenesis is under the influence of both proand anti-angiogenesis factors. Of these, vascular endothelial growth factor (VEGF) and its family of receptors play a key role in the regulation of angiogenesis. The VEGF gene family consists of several members including placenta growth factor (PIGF), VEGF-A, VEGF-B, VEGF-C and VEGF-D, but VEGF-A (often referred to as VEGF) is the dominant protein (Ferrara, 2003). The VEGF receptor family consists of three members including VEGFR-1(Flt-1), VEGFR-2 (KDR or Flk-1), and VEGFR-3 (Flt-4). Given the key role of VEGF and its family of receptors in regulating angiogenesis, inhibitors of both VEGF and its receptors are actively being developed as anti-cancer therapies. To inhibit the VEGF pathway two different options are used: 1. VEGF ligand inhibition by antibodies or soluble receptors 2. VEGF receptor inhibition by tyrosine kinase inhibitor (TKIs) or receptor antibodies" @default.
• W1540564953 created "2016-06-24" @default.
• W1540564953 creator A5018949334 @default.
• W1540564953 creator A5024419542 @default.
• W1540564953 creator A5037624587 @default.
• W1540564953 creator A5039514062 @default.
• W1540564953 creator A5043060002 @default.
• W1540564953 creator A5084545133 @default.
• W1540564953 date "2011-12-09" @default.
• W1540564953 modified "2023-09-27" @default.
• W1540564953 title "Antiangiogenic Treatment Concepts in Gynecologic Oncology" @default.
• W1540564953 cites W1756949381 @default.
• W1540564953 cites W1978139448 @default.
• W1540564953 cites W1980499812 @default.
• W1540564953 cites W1994855668 @default.
• W1540564953 cites W2000292756 @default.
• W1540564953 cites W2001403404 @default.
• W1540564953 cites W2013427440 @default.
• W1540564953 cites W2013542926 @default.
• W1540564953 cites W2015919139 @default.
• W1540564953 cites W2017414151 @default.
• W1540564953 cites W2018212343 @default.
• W1540564953 cites W2028070610 @default.
• W1540564953 cites W2041766813 @default.
• W1540564953 cites W2049454219 @default.
• W1540564953 cites W2053358495 @default.
• W1540564953 cites W2063194925 @default.
• W1540564953 cites W2080861151 @default.
• W1540564953 cites W2099348884 @default.
• W1540564953 cites W2109400578 @default.
• W1540564953 cites W2122815596 @default.
• W1540564953 cites W2130374103 @default.
• W1540564953 cites W2132193955 @default.
• W1540564953 cites W2151050516 @default.
• W1540564953 cites W2154516141 @default.
• W1540564953 cites W2166260885 @default.
• W1540564953 cites W2170825221 @default.
• W1540564953 cites W2244256264 @default.
• W1540564953 cites W2266936611 @default.
• W1540564953 cites W2317557137 @default.
• W1540564953 cites W2336729376 @default.
• W1540564953 cites W2494366594 @default.
• W1540564953 cites W3000431466 @default.
• W1540564953 doi "https://doi.org/10.5772/25195" @default.
• W1540564953 hasPublicationYear "2011" @default.
• W1540564953 type Work @default.
• W1540564953 sameAs 1540564953 @default.
• W1540564953 citedByCount "0" @default.
• W1540564953 crossrefType "book-chapter" @default.
• W1540564953 hasAuthorship W1540564953A5018949334 @default.
• W1540564953 hasAuthorship W1540564953A5024419542 @default.
• W1540564953 hasAuthorship W1540564953A5037624587 @default.
• W1540564953 hasAuthorship W1540564953A5039514062 @default.
• W1540564953 hasAuthorship W1540564953A5043060002 @default.
• W1540564953 hasAuthorship W1540564953A5084545133 @default.
• W1540564953 hasBestOaLocation W15405649531 @default.
• W1540564953 hasConcept C121608353 @default.
• W1540564953 hasConcept C126322002 @default.
• W1540564953 hasConcept C143998085 @default.
• W1540564953 hasConcept C2777088508 @default.
• W1540564953 hasConcept C2778220009 @default.
• W1540564953 hasConcept C2780394083 @default.
• W1540564953 hasConcept C2780427987 @default.
• W1540564953 hasConcept C2780435969 @default.
• W1540564953 hasConcept C2992773878 @default.
• W1540564953 hasConcept C2994372414 @default.
• W1540564953 hasConcept C71924100 @default.
• W1540564953 hasConceptScore W1540564953C121608353 @default.
• W1540564953 hasConceptScore W1540564953C126322002 @default.
• W1540564953 hasConceptScore W1540564953C143998085 @default.
• W1540564953 hasConceptScore W1540564953C2777088508 @default.
• W1540564953 hasConceptScore W1540564953C2778220009 @default.
• W1540564953 hasConceptScore W1540564953C2780394083 @default.
• W1540564953 hasConceptScore W1540564953C2780427987 @default.
• W1540564953 hasConceptScore W1540564953C2780435969 @default.
• W1540564953 hasConceptScore W1540564953C2992773878 @default.
• W1540564953 hasConceptScore W1540564953C2994372414 @default.
• W1540564953 hasConceptScore W1540564953C71924100 @default.
• W1540564953 hasLocation W15405649531 @default.
• W1540564953 hasLocation W15405649532 @default.
• W1540564953 hasOpenAccess W1540564953 @default.
• W1540564953 hasPrimaryLocation W15405649531 @default.
• W1540564953 hasRelatedWork W136845538 @default.
• W1540564953 hasRelatedWork W1551121103 @default.
• W1540564953 hasRelatedWork W2008492649 @default.
• W1540564953 hasRelatedWork W2026169552 @default.
• W1540564953 hasRelatedWork W2049769364 @default.
• W1540564953 hasRelatedWork W2075026340 @default.
• W1540564953 hasRelatedWork W2080997194 @default.
• W1540564953 hasRelatedWork W2096797602 @default.
• W1540564953 hasRelatedWork W2115508346 @default.
• W1540564953 hasRelatedWork W2130027054 @default.
• W1540564953 hasRelatedWork W2153290867 @default.
• W1540564953 hasRelatedWork W2154502317 @default.
• W1540564953 hasRelatedWork W2162511447 @default.
• W1540564953 hasRelatedWork W2338661053 @default.
• W1540564953 hasRelatedWork W2398710458 @default.
• W1540564953 hasRelatedWork W2417426465 @default.
• W1540564953 hasRelatedWork W2903825979 @default.
• W1540564953 hasRelatedWork W2930873894 @default.

• next