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- W1540592014 endingPage "e1792" @default.
- W1540592014 startingPage "e1792" @default.
- W1540592014 abstract "T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials." @default.
- W1540592014 created "2016-06-24" @default.
- W1540592014 creator A5010422757 @default.
- W1540592014 creator A5012442991 @default.
- W1540592014 creator A5027562367 @default.
- W1540592014 date "2015-06-18" @default.
- W1540592014 modified "2023-10-18" @default.
- W1540592014 title "T-cell exhaustion in the tumor microenvironment" @default.
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