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• W1540604562 startingPage "557" @default.
• W1540604562 abstract "A number of different viral spike proteins, responsible for membrane fusion, show striking similarities in their core structures. The prospect of developing a general structure-based mechanism seems plausible in light of these newly determined structures. Influenza hemagglutinin (HA) is the best-studied fusion machine, whose action has previously been described by a hypothetical spring-loaded model. This model has recently been extended to explain the mechanism of other systems, such as HIV gp120-gp41. However, evidence supporting this idea is insufficient, requiring re-examination of the mechanism of HA-induced membrane fusion. Recent experiments with a shortened construct of HA, which is able to induce lipid mixing, have provided evidence for an alternative scenario for HA-induced membrane fusion and perhaps that of other viral systems." @default.
• W1540604562 created "2016-06-24" @default.
• W1540604562 creator A5007579590 @default.
• W1540604562 creator A5076215592 @default.
• W1540604562 date "2000-12-01" @default.
• W1540604562 modified "2023-10-14" @default.
• W1540604562 title "Insights into a Structure-Based Mechanism of Viral Membrane Fusion" @default.
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• W1540604562 doi "https://doi.org/10.1023/a:1010463005396" @default.
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