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- W1540746722 startingPage "339" @default.
- W1540746722 abstract "Bacillus subtilis can be regarded as one of the best characterized representatives of Gram-positive bacteria known so far. The complex mechanisms of stress, starvation and antibiotic responses have been widely studied in B. subtilis over the last ten years using functional genomics, genetic and biochemistry. One of the challenges of the proteomic approach in the post-genomic area is to study post-translational control mechanisms, targeting, modifications, damage, aggregation and repair mechanisms of proteins. In this review, we demonstrate that gel-based proteomics is an essential tool to understand the “life of the proteins” in a bacterial cell and in following bacterial physiology at a global scale. Different proteomic tools can be applied to address diverse physiological question which will be summarized in this work. For example, the analysis of the protein synthesis pattern is especially suited to study protein expression profiles and regulon structures and the thiol-redox proteome can be applied to analyze reversible thiol modifications. Finally, the analysis of different subproteomic fractions such as extracellular and surface-associated proteins can gain insights into protein secretion mechanisms, protein targeting and localization. The next challenge is to select the most interesting results of these proteomic approaches for detailed genetic and molecular studies to come to novel exciting mechanisms of bacterial physiology." @default.
- W1540746722 created "2016-06-24" @default.
- W1540746722 creator A5020611058 @default.
- W1540746722 creator A5082748007 @default.
- W1540746722 date "2010-06-15" @default.
- W1540746722 modified "2023-10-18" @default.
- W1540746722 title "The Proteomic Road Map to Explore Novel Mechanisms of Bacterial Physiology" @default.
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