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• W1540802235 abstract "Haloperidol used alone is recommended to help calm situations of aggression or agitation for people with psychosis. It is widely accessible and may be the only antipsychotic medication available in limited-resource areas.To examine whether haloperidol alone is an effective treatment for psychosis-induced aggression or agitation, wherein clinicians are required to intervene to prevent harm to self and others.We searched the Cochrane Schizophrenia Group's Study-Based Register of Trials (26th May 2016). This register is compiled by systematic searches of major resources (including AMED, BIOSIS CINAHL, Embase, MEDLINE, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings, with no language, date, document type, or publication status limitations for inclusion of records into the register.Randomised controlled trials (RCTs) involving people exhibiting aggression and/or agitation thought to be due to psychosis, allocated rapid use of haloperidol alone (by any route), compared with any other treatment. Outcomes of interest included tranquillisation or asleep by 30 minutes, repeated need for rapid tranquillisation within 24 hours, specific behaviours (threat or injury to others/self), adverse effects. We included trials meeting our selection criteria and providing useable data.We independently inspected all citations from searches, identified relevant abstracts, and independently extracted data from all included studies. For binary data we calculated risk ratio (RR), for continuous data we calculated mean difference (MD), and for cognitive outcomes we derived standardised mean difference (SMD) effect sizes, all with 95% confidence intervals (CI) and using a fixed-effect model. We assessed risk of bias for the included studies and used the GRADE approach to produce 'Summary of findings' tables which included our pre-specified main outcomes of interest.We found nine new RCTs from the 2016 update search, giving a total of 41 included studies and 24 comparisons. Few studies were undertaken in circumstances that reflect real-world practice, and, with notable exceptions, most were small and carried considerable risk of bias. Due to the large number of comparisons, we can only present a summary of main results.Compared with placebo, more people in the haloperidol group were asleep at two hours (2 RCTs, n=220, RR 0.88, 95%CI 0.82 to 0.95, very low-quality evidence) and experienced dystonia (2 RCTs, n=207, RR 7.49, 95%CI 0.93 to 60.21, very low-quality evidence).Compared with aripiprazole, people in the haloperidol group required fewer injections than those in the aripiprazole group (2 RCTs, n=473, RR 0.78, 95%CI 0.62 to 0.99, low-quality evidence). More people in the haloperidol group experienced dystonia (2 RCTs, n=477, RR 6.63, 95%CI 1.52 to 28.86, very low-quality evidence).Four trials (n=207) compared haloperidol with lorazepam with no significant differences with regard to number of participants asleep at one hour (1 RCT, n=60, RR 1.05, 95%CI 0.76 to 1.44, very low-quality of evidence) or those requiring additional injections (1 RCT, n=66, RR 1.14, 95%CI 0.91 to 1.43, very low-quality of evidence).Haloperidol's adverse effects were not offset by addition of lorazepam (e.g. dystonia 1 RCT, n=67, RR 8.25, 95%CI 0.46 to 147.45, very low-quality of evidence).Addition of promethazine was investigated in two trials (n=376). More people in the haloperidol group were not tranquil or asleep by 20 minutes (1 RCT, n=316, RR 1.60, 95%CI 1.18 to 2.16, moderate-quality evidence). Acute dystonia was too common in the haloperidol alone group for the trial to continue beyond the interim analysis (1 RCT, n=316, RR 19.48, 95%CI 1.14 to 331.92, low-quality evidence).Additional data from new studies does not alter previous conclusions of this review. If no other alternative exists, sole use of intramuscular haloperidol could be life-saving. Where additional drugs are available, sole use of haloperidol for extreme emergency could be considered unethical. Addition of the sedating promethazine has support from better-grade evidence from within randomised trials. Use of an alternative antipsychotic drug is only partially supported by fragmented and poor-grade evidence. Adding a benzodiazepine to haloperidol does not have strong evidence of benefit and carries risk of additional harm.After six decades of use for emergency rapid tranquillisation, this is still an area in need of good independent trials relevant to real-world practice." @default.
• W1540802235 created "2016-06-24" @default.
• W1540802235 creator A5033684035 @default.
• W1540802235 creator A5047521970 @default.
• W1540802235 creator A5066526275 @default.
• W1540802235 creator A5085074957 @default.
• W1540802235 date "2017-07-31" @default.
• W1540802235 modified "2023-10-17" @default.
• W1540802235 title "Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation)" @default.
• W1540802235 cites W116816145 @default.
• W1540802235 cites W1486325792 @default.
• W1540802235 cites W1510018163 @default.
• W1540802235 cites W1517837731 @default.
• W1540802235 cites W152000104 @default.
• W1540802235 cites W1533806909 @default.
• W1540802235 cites W1536365506 @default.
• W1540802235 cites W1540802235 @default.
• W1540802235 cites W1542810171 @default.
• W1540802235 cites W1551675370 @default.
• W1540802235 cites W1554704723 @default.
• W1540802235 cites W1591259115 @default.
• W1540802235 cites W1593456566 @default.
• W1540802235 cites W1691073820 @default.
• W1540802235 cites W1711188166 @default.
• W1540802235 cites W1724131819 @default.
• W1540802235 cites W175331120 @default.
• W1540802235 cites W1758155888 @default.
• W1540802235 cites W1759768202 @default.
• W1540802235 cites W177230180 @default.
• W1540802235 cites W1869588275 @default.
• W1540802235 cites W1884039895 @default.
• W1540802235 cites W1892463399 @default.
• W1540802235 cites W1930750863 @default.
• W1540802235 cites W1931585301 @default.
• W1540802235 cites W1963747265 @default.
• W1540802235 cites W1964162160 @default.
• W1540802235 cites W1964320139 @default.
• W1540802235 cites W1965135842 @default.
• W1540802235 cites W1969475028 @default.
• W1540802235 cites W1975179169 @default.
• W1540802235 cites W1976178155 @default.
• W1540802235 cites W1976493394 @default.
• W1540802235 cites W1976791378 @default.
• W1540802235 cites W1977185679 @default.
• W1540802235 cites W1977205937 @default.
• W1540802235 cites W1978040764 @default.
• W1540802235 cites W1978978302 @default.
• W1540802235 cites W1979597308 @default.
• W1540802235 cites W1979819977 @default.
• W1540802235 cites W1982016174 @default.
• W1540802235 cites W1983625342 @default.
• W1540802235 cites W1985313354 @default.
• W1540802235 cites W1990148777 @default.
• W1540802235 cites W1992857340 @default.
• W1540802235 cites W1992870119 @default.
• W1540802235 cites W1994066656 @default.
• W1540802235 cites W1995211010 @default.
• W1540802235 cites W1999689270 @default.
• W1540802235 cites W2000239143 @default.
• W1540802235 cites W2000352002 @default.
• W1540802235 cites W2001135246 @default.
• W1540802235 cites W2005710535 @default.
• W1540802235 cites W2007001227 @default.
• W1540802235 cites W2009475017 @default.
• W1540802235 cites W2010517846 @default.
• W1540802235 cites W2011449571 @default.
• W1540802235 cites W2013902956 @default.
• W1540802235 cites W2015465788 @default.
• W1540802235 cites W2016056256 @default.
• W1540802235 cites W2019242543 @default.
• W1540802235 cites W2019758393 @default.
• W1540802235 cites W2020844317 @default.
• W1540802235 cites W2022657724 @default.
• W1540802235 cites W2023839473 @default.
• W1540802235 cites W2025926616 @default.
• W1540802235 cites W2027123980 @default.
• W1540802235 cites W2027198501 @default.
• W1540802235 cites W2030437868 @default.
• W1540802235 cites W2032712358 @default.
• W1540802235 cites W2034462924 @default.
• W1540802235 cites W2034528813 @default.
• W1540802235 cites W2034845725 @default.
• W1540802235 cites W2035864316 @default.
• W1540802235 cites W2045855020 @default.
• W1540802235 cites W2045865877 @default.
• W1540802235 cites W2045947066 @default.
• W1540802235 cites W2047151309 @default.
• W1540802235 cites W2047696957 @default.
• W1540802235 cites W2047744581 @default.
• W1540802235 cites W2048382616 @default.
• W1540802235 cites W2050056114 @default.
• W1540802235 cites W2050902251 @default.
• W1540802235 cites W2051204133 @default.
• W1540802235 cites W2051607778 @default.
• W1540802235 cites W2052198771 @default.
• W1540802235 cites W2056605978 @default.
• W1540802235 cites W2058874144 @default.
• W1540802235 cites W2059038338 @default.
• W1540802235 cites W2060020222 @default.
• W1540802235 cites W2060455360 @default.

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