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- W1540884075 abstract "textabstractIn mice hemopoietic stem cells and progenitor cells arealmost totally confined to the bone marrow and spleen. Onlysmall numbers can be detected in the peripheral blood.Relatively little is known about the mechanism(s) modulatingthe circulation and mobilization of stem cells. At presenttheir function and ultimate fate are unknown. Mobilizationof hemopoietic stem cells in mice has been achieved byinjection of a variety of substances, the most well knownbeing LPS. For some substances, including endotoxin, thetransient increase in blood CFU-s immediately followinginjection (early mobilization) is followed by a second onesome days later (delayed mobilization).The purpose of the investigations presented in thisthesis was to get insight into the mechanism(s) underlyingboth early and delayed mobilization of hemopoietic stemcells by LPS and other agents. Additionally, the changes insplenic hemopoiesis seen after administration of LPS havebeen subject of investigation" @default.
- W1540884075 created "2016-06-24" @default.
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- W1540884075 date "1987-02-18" @default.
- W1540884075 modified "2023-09-26" @default.
- W1540884075 title "Hemopoietic stem cell mobilization in mice" @default.
- W1540884075 hasPublicationYear "1987" @default.
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