Matches in SemOpenAlex for { <https://semopenalex.org/work/W1541007005> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1541007005 endingPage "23" @default.
- W1541007005 startingPage "216" @default.
- W1541007005 abstract "Pharmacological disposition of chloramphenicol was studied in horses. Minimum levels of the antibiotic (greater than or equal to 5 mu g/ml) in blood or plasma recommended to combat infections could not be achieved by 4.4 and 8.8 mg/kg I.V. or 30 and 50 mg/kg I.M. or 30 mg/kg oral (as palmitate salt) doses of chloramphenicol. Increasing the dose to 19.8 and 26.4 mg/kg I.V. provided such levels for about two and three hours respectively. A combination of 20 mg/kg I.V. and 30 mg/kg I.M. administered simultaneously did not provide more prolonged levels than 26.4 mg/kg I.V. alone. Chloramphenicol succinate produced higher but not more prolonged levels in blood and plasma than those produced by pure chloramphenicol. Succinate salt is very little, if at all, bound to red blood corpuscles. Plasma half life and the apparent volume of distribution of chloramphenicol in horses were determined as 0.98 hours and 0.92 L/kg, respectively. At 5-10 mu g/ml concentrations in equine plasma approximately 30 percent of the chloramphenicol is bound to plasma proteins. From these studies it is concluded that the biological half life of chloramphenicol may be too short for therapeutic application against systemic infections in horses." @default.
- W1541007005 created "2016-06-24" @default.
- W1541007005 creator A5008238000 @default.
- W1541007005 creator A5008994412 @default.
- W1541007005 creator A5051741553 @default.
- W1541007005 creator A5053867915 @default.
- W1541007005 creator A5083074718 @default.
- W1541007005 date "1975-04-01" @default.
- W1541007005 modified "2023-09-27" @default.
- W1541007005 title "A pharmacological study of chloramphenicol in horses." @default.
- W1541007005 cites W176419229 @default.
- W1541007005 cites W1775749144 @default.
- W1541007005 cites W1965266818 @default.
- W1541007005 cites W2071198522 @default.
- W1541007005 cites W2082776812 @default.
- W1541007005 cites W2316764189 @default.
- W1541007005 cites W2409893572 @default.
- W1541007005 cites W2410516712 @default.
- W1541007005 cites W2440634202 @default.
- W1541007005 cites W2464821269 @default.
- W1541007005 cites W276986765 @default.
- W1541007005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1277444" @default.
- W1541007005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1125836" @default.
- W1541007005 hasPublicationYear "1975" @default.
- W1541007005 type Work @default.
- W1541007005 sameAs 1541007005 @default.
- W1541007005 citedByCount "1" @default.
- W1541007005 countsByYear W15410070052012 @default.
- W1541007005 crossrefType "journal-article" @default.
- W1541007005 hasAuthorship W1541007005A5008238000 @default.
- W1541007005 hasAuthorship W1541007005A5008994412 @default.
- W1541007005 hasAuthorship W1541007005A5051741553 @default.
- W1541007005 hasAuthorship W1541007005A5053867915 @default.
- W1541007005 hasAuthorship W1541007005A5083074718 @default.
- W1541007005 hasConcept C126322002 @default.
- W1541007005 hasConcept C140793950 @default.
- W1541007005 hasConcept C185592680 @default.
- W1541007005 hasConcept C2776575606 @default.
- W1541007005 hasConcept C2778473333 @default.
- W1541007005 hasConcept C501593827 @default.
- W1541007005 hasConcept C55493867 @default.
- W1541007005 hasConcept C71924100 @default.
- W1541007005 hasConcept C86803240 @default.
- W1541007005 hasConcept C98274493 @default.
- W1541007005 hasConceptScore W1541007005C126322002 @default.
- W1541007005 hasConceptScore W1541007005C140793950 @default.
- W1541007005 hasConceptScore W1541007005C185592680 @default.
- W1541007005 hasConceptScore W1541007005C2776575606 @default.
- W1541007005 hasConceptScore W1541007005C2778473333 @default.
- W1541007005 hasConceptScore W1541007005C501593827 @default.
- W1541007005 hasConceptScore W1541007005C55493867 @default.
- W1541007005 hasConceptScore W1541007005C71924100 @default.
- W1541007005 hasConceptScore W1541007005C86803240 @default.
- W1541007005 hasConceptScore W1541007005C98274493 @default.
- W1541007005 hasIssue "2" @default.
- W1541007005 hasLocation W15410070051 @default.
- W1541007005 hasOpenAccess W1541007005 @default.
- W1541007005 hasPrimaryLocation W15410070051 @default.
- W1541007005 hasRelatedWork W1973263627 @default.
- W1541007005 hasRelatedWork W203523426 @default.
- W1541007005 hasRelatedWork W2061603097 @default.
- W1541007005 hasRelatedWork W2103005331 @default.
- W1541007005 hasRelatedWork W2182909895 @default.
- W1541007005 hasRelatedWork W2410336233 @default.
- W1541007005 hasRelatedWork W2416429061 @default.
- W1541007005 hasRelatedWork W2748952813 @default.
- W1541007005 hasRelatedWork W2899084033 @default.
- W1541007005 hasRelatedWork W2592794680 @default.
- W1541007005 hasVolume "39" @default.
- W1541007005 isParatext "false" @default.
- W1541007005 isRetracted "false" @default.
- W1541007005 magId "1541007005" @default.
- W1541007005 workType "article" @default.