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- W1541027360 abstract "Hypertension represents an enormous health care burden in Western societies. Approximately 30% of the Western population and 70% of adults over 70 years of age are afflicted with this disease [1]. Another 30% of the population has prehypertension, defined as systolic blood pressure of 120–139 mm Hg, and these indi vid-uals commonly progress to have overt hyper-tension within 4 years [2]. While the overall prevalence of hypertension in the United States has remained constant over the past decade, its incidence in young adults (aged 18–39 years) has increased from 27.6% in 1999 to 49.1% in 2008. The overall annual healthcare cost of hypertension in the United States was recently estimated to be over $93.5 billion [3].The clinical sequelae of hypertension are largely related to end-organ insults including renal failure, stroke, myocardial hypertrophy, heart failure, and vascular disease. The vascular consequences of hypertension include alterations of vascular reactivity, vascular hypertrophy, fibrosis, dropout or rarefaction of smaller ves-sels, and a striking predilection to atheroscle-rosis. The mechanisms by which hypertension promotes atherosclerosis remain a matter of continued investigation. In this chapter, we will review the molecular, cellular, and hemodynamic factors that link hypertension with atheroscle-rosis and discuss future directions for research and potential therapeutic implications." @default.
- W1541027360 created "2016-06-24" @default.
- W1541027360 creator A5011627807 @default.
- W1541027360 creator A5091099970 @default.
- W1541027360 date "2015-03-27" @default.
- W1541027360 modified "2023-10-17" @default.
- W1541027360 title "Hypertension as a Risk Factor for Atherosclerosis" @default.
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- W1541027360 doi "https://doi.org/10.1002/9781118828533.ch6" @default.
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