FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1541174964> ?p ?o ?g. }

• W1541174964 endingPage "206" @default.
• W1541174964 startingPage "199" @default.
• W1541174964 abstract "To assess the efficacy of a protocol involving the discontinuation of the GnRH analogue at the mid-phase of ovarian stimulation for IVF in patients with a previous poor response.Prospective case-control evaluation compared with same patient's previous performance. Thirty-six patients enrolled in an IVF program were treated in two consecutive cycles. The first with a standardized protocol utilizing midluteal administration of Nafarelin (N) 600 mcg/d continued throughout the stimulation phase with human menopausal gonadotropin (hMG) until follicles of 20 mm were identified by transvaginal ultrasound (Standard group). Patients with a poor response in the Standard cycle were treated in the subsequent cycle with N and hMG initially in a similar manner, then N was stopped after 5 days of hMG stimulation (N-stop group). All clinical and laboratory aspects of treatment were done in a similar fashion in both cycles, each patient acting as her own control.Results were analyzed by paired t test. The change in each parameter in the N-stop cycle was expressed as the percent change as compared with the standard protocol cycle for each patient. Peak estradiol (E2) and number of aspirated oocytes were increased in the N-stop cycle (+16.9% and +28%, respectively), but insignificantly so. The percent of cleaving embryos was significantly increased by 27.9% (p = 0.03) in the N-stop cycle, as embryo morphology was improved by 22% (p = 0.02). The efficacy of gonadotropin treatment was enhanced in the N-stop cycle, as expressed by a 32.5% increase in oocytes retrieved per hMG ampoule administered (p = 0.04). Three cycles of 36 were cancelled during the N-stop cycle, whereas only one was cancelled in the standard protocol cycle. Of the 36 patients, 7 conceived in the N-stop protocol and 5 are ongoing pregnancies.Discontinuation of GnRH-a during ovarian stimulation for IVF has a beneficial, but not statistically significant, effect on both E2 and oocyte production. Embryo cleavage rates and morphology were significantly improved, this may be due to improved oocyte quality, which may have been responsible for achieving pregnancies. The efficacy of gonadotropin treatment was enhanced when GnRH-a was discontinued. These results hint that GnRH-a may have a direct negative effect on folliculogenesis and oocytes, which is apparent especially in poor responder patients." @default.
• W1541174964 created "2016-06-24" @default.
• W1541174964 creator A5007112381 @default.
• W1541174964 creator A5014494785 @default.
• W1541174964 creator A5015241305 @default.
• W1541174964 creator A5034927124 @default.
• W1541174964 creator A5064263844 @default.
• W1541174964 creator A5071047398 @default.
• W1541174964 date "2001-01-01" @default.
• W1541174964 modified "2023-10-17" @default.
• W1541174964 cites W107570177 @default.
• W1541174964 cites W1565672383 @default.
• W1541174964 cites W1964629309 @default.
• W1541174964 cites W1970925133 @default.
• W1541174964 cites W1977735968 @default.
• W1541174964 cites W1978381548 @default.
• W1541174964 cites W2020610362 @default.
• W1541174964 cites W2021800615 @default.
• W1541174964 cites W2030988675 @default.
• W1541174964 cites W2045961792 @default.
• W1541174964 cites W2061786425 @default.
• W1541174964 cites W2062952618 @default.
• W1541174964 cites W2066764799 @default.
• W1541174964 cites W2077293092 @default.
• W1541174964 cites W2086640680 @default.
• W1541174964 cites W2095841239 @default.
• W1541174964 cites W2109374046 @default.
• W1541174964 cites W2110367951 @default.
• W1541174964 cites W2136283467 @default.
• W1541174964 cites W2155924023 @default.
• W1541174964 cites W2165510178 @default.
• W1541174964 cites W2166386830 @default.
• W1541174964 cites W2170773973 @default.
• W1541174964 cites W2252293870 @default.
• W1541174964 cites W2265175330 @default.
• W1541174964 cites W2280615188 @default.
• W1541174964 cites W2282666121 @default.
• W1541174964 cites W2396968125 @default.
• W1541174964 cites W2398110179 @default.
• W1541174964 cites W2404784295 @default.
• W1541174964 cites W2405223247 @default.
• W1541174964 cites W2409529349 @default.
• W1541174964 cites W2412789611 @default.
• W1541174964 cites W2413821991 @default.
• W1541174964 cites W2415299454 @default.
• W1541174964 cites W6532098 @default.
• W1541174964 cites W2398817324 @default.
• W1541174964 doi "https://doi.org/10.1023/a:1009476411762" @default.
• W1541174964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3455367" @default.
• W1541174964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11432110" @default.
• W1541174964 hasPublicationYear "2001" @default.
• W1541174964 type Work @default.
• W1541174964 sameAs 1541174964 @default.
• W1541174964 citedByCount "34" @default.
• W1541174964 countsByYear W15411749642012 @default.
• W1541174964 countsByYear W15411749642014 @default.
• W1541174964 countsByYear W15411749642015 @default.
• W1541174964 countsByYear W15411749642016 @default.
• W1541174964 countsByYear W15411749642017 @default.
• W1541174964 countsByYear W15411749642018 @default.
• W1541174964 countsByYear W15411749642021 @default.
• W1541174964 countsByYear W15411749642022 @default.
• W1541174964 crossrefType "journal-article" @default.
• W1541174964 hasAuthorship W1541174964A5007112381 @default.
• W1541174964 hasAuthorship W1541174964A5014494785 @default.
• W1541174964 hasAuthorship W1541174964A5015241305 @default.
• W1541174964 hasAuthorship W1541174964A5034927124 @default.
• W1541174964 hasAuthorship W1541174964A5064263844 @default.
• W1541174964 hasAuthorship W1541174964A5071047398 @default.
• W1541174964 hasBestOaLocation W15411749642 @default.
• W1541174964 hasConcept C104950815 @default.
• W1541174964 hasConcept C126322002 @default.
• W1541174964 hasConcept C134651460 @default.
• W1541174964 hasConcept C16685009 @default.
• W1541174964 hasConcept C181199279 @default.
• W1541174964 hasConcept C24998067 @default.
• W1541174964 hasConcept C2777702977 @default.
• W1541174964 hasConcept C2778715236 @default.
• W1541174964 hasConcept C2778782382 @default.
• W1541174964 hasConcept C2779058012 @default.
• W1541174964 hasConcept C2781230225 @default.
• W1541174964 hasConcept C29456083 @default.
• W1541174964 hasConcept C55493867 @default.
• W1541174964 hasConcept C71315377 @default.
• W1541174964 hasConcept C71924100 @default.
• W1541174964 hasConcept C86803240 @default.
• W1541174964 hasConceptScore W1541174964C104950815 @default.
• W1541174964 hasConceptScore W1541174964C126322002 @default.
• W1541174964 hasConceptScore W1541174964C134651460 @default.
• W1541174964 hasConceptScore W1541174964C16685009 @default.
• W1541174964 hasConceptScore W1541174964C181199279 @default.
• W1541174964 hasConceptScore W1541174964C24998067 @default.
• W1541174964 hasConceptScore W1541174964C2777702977 @default.
• W1541174964 hasConceptScore W1541174964C2778715236 @default.
• W1541174964 hasConceptScore W1541174964C2778782382 @default.
• W1541174964 hasConceptScore W1541174964C2779058012 @default.
• W1541174964 hasConceptScore W1541174964C2781230225 @default.
• W1541174964 hasConceptScore W1541174964C29456083 @default.

• next