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- W1541194803 abstract "OBJECTIVE: To determine whether left ventricular hypertrophy(LVH) is associated with white matter hyperintensities (WMH) in young adults with stroke independent of history of hypertension(HTN). BACKGROUND: We recently reported a high prevalence of WMH in a population of young adults with stroke. WMH is a radiographic marker of cerebral small vessel disease occurring most notably from hypertensive vasculopathy. LVH is a consequence of chronic HTN. Accordingly, it may be a better predictor of cerebral small vessel disease than a known history of HTN, which is likely underestimated due to 24h blood pressure variability. DESIGN/METHODS: We retrospectively reviewed data of 146 patients aged 18-49 years admitted consecutively to Boston Medical Center between 01/2006-02/2010 with a new diagnosis of ischemic or hemorrhagic stroke. Patients with interpretable T2/FLAIR sequences on MRI and echocardiograms on admission were eligible (n=107). WMH was graded according to the Age-Related White Matter Changes Scale. LVH was defined as any degree of LVH per transthoracic-echocardiogram. We compared the association of LVH with moderate-severe WMH in both univariate and multivariate analyses to none-mild WMH.RESULTS: Moderate-severe WMH was present in 27% of patients (mean age 41 years). LVH was present in 30%. Nine percent of the population had LVH without history of HTN. Patients with moderate-severe WMH were more likely to be hypertensive (40% vs. 12%,p=0.001), and to have LVH (44% vs. 20%,p=0.01). In multivariate analysis adjusted for age and known history of HTN, both history of HTN (OR 3.75 [95% CI, 1.31-10.7]) and LVH (OR 2.62 [95% CI, 1.01-6.74]) were independently associated with presence of moderate-severe WMH.CONCLUSIONS: A large proportion of WMH in our cohort is hypertensive. Our preliminary data suggest that LVH may aid in determining the pathophysiology underlying WMH in young adults with stroke, independent from HTN. Further analyses are needed to confirm our findings.Study Supported by: None Disclosure: Dr. Catanese has nothing to disclose. Dr. Shoamanesh has nothing to disclose. Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Babikian has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Pikula has nothing to disclose." @default.
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- W1541194803 date "2014-04-08" @default.
- W1541194803 modified "2023-09-30" @default.
- W1541194803 title "Left Ventricular Hypertrophy as a Predictor of White Matter Hyperintensities in Young Stroke Patients (P2.111)" @default.
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