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- W1541566504 abstract "The desoxyhemoglobin S polymerization, characterized by the delay time or nucleation, constitutes the primary physiopathologic event of the sickle cell disease. An effective treatment doesn’t still exist and they are studied compound that inhibit the hemoglobin S polymerization and the red cell sickling. The moderate antisickling activity of a food additive 4-hydroxy-3-methoxybenzaldehyde (vanillin), at 1:4, 1:5, 1:6, 1:7 and 1:8 molar ratio (hemoglobin:vanillin), it was evaluated in vitro by means of their effect on the delay time using the Proton Nuclear Magnetic Resonance (RMN-1H). To specify the absence of cytotoxic activity of the vanillin on sickle red blood cells it was evaluated the effect of the molar ratios (1:1, 1:2, 1:4, 1:5, 1:8 and 1:10) on the hemoglobin liberation and it was compared with normal red blood cells. The vanillin increased the delay time and its variation percentage was 17±8% (1:4), 21±15% (1:5), 28±14% (1:6), 23±10% (1:7) and 35±26% (1:8), being observed a dose dependent effect on the retard of the polymerization. The test of multiple comparison reported non significant differences among the work concentrations (p>0.05). A low percentage of hemolysis was obtained with a small increase for the molar ratio 1:10 when compared with the rest (p<0.05%). Although a tendency was not obtained in the whole study; being demonstrated the absence of cytotoxics effects for red blood cells, their target of pharmacological action." @default.
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- W1541566504 date "2003-01-01" @default.
- W1541566504 modified "2023-09-24" @default.
- W1541566504 title "Vainillina: agente inhibidor de la polimerización de la hemoglobina S" @default.
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