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- W1541618356 abstract "Abstract: Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper type-17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3+ cells in peripheral blood mononuclear cells (PBMC) obtained from 27 healthy volunteers (2.58 ± 0.80%), 33 smoker (3.55 ± 1.33%) and 21 non-smoker (3.10 ± 1.14%) patients with psoriasis to elucidate the relation between smoking and psoriasis. More smokers (19/33) than non-smokers (6/21) had high Th17 levels (Th17/CD3 > 3.38%, mean + 1 SD of healthy volunteers). Tobacco smoke extract (TSE, 7 μl/ml) induced Th17 generation from central memory T cells in vitro. TSE increased interleukin 17 and 22 expression. These findings demonstrate the relation between tobacco smoke and IL-17 and IL-22, which exacerbate psoriasis." @default.
- W1541618356 created "2016-06-24" @default.
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- W1541618356 date "2011-02-28" @default.
- W1541618356 modified "2023-10-01" @default.
- W1541618356 title "Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients" @default.
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- W1541618356 doi "https://doi.org/10.1111/j.1600-0625.2010.01224.x" @default.
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